遗传学报
遺傳學報
유전학보
ACTA GENETICA SINICA
2004年
9期
941-949
,共9页
余运贤%Scott A.Venners%牛天华%陈常中%黄爱群%张岩%冯雁%李栋%邢厚询%吴迪%彭少杰%徐希平
餘運賢%Scott A.Venners%牛天華%陳常中%黃愛群%張巖%馮雁%李棟%邢厚詢%吳迪%彭少傑%徐希平
여운현%Scott A.Venners%우천화%진상중%황애군%장암%풍안%리동%형후순%오적%팽소걸%서희평
原发性高血压%α-Adducin%多态性%胆红素%遗传学
原髮性高血壓%α-Adducin%多態性%膽紅素%遺傳學
원발성고혈압%α-Adducin%다태성%담홍소%유전학
essential hypertension%α-adducin%polymorphism%bilirubin%genetics
探讨了自2000年9月到2001年1月来自安徽省霍邱县地区原发性高血压人群中α-Adducin基因单核苷酸多态性与血清中总胆红素、直接胆红素和间接胆红素含量的相关性.在原发性高血压女性患者中,在校正了许多可能影响胆红素含量的重要因素后,与携带有Gly460Gly基因型的高血压女性患者相比较,携带有Trp460Trp基因型的高血压女性患者血清平均总胆红素 (β= -1.2 μmol/L;P=0.01)、直接胆红素(β= -0.4 μmol/L;P=0.02)和间接胆红素(β= -0.8 μmol/L;P=0.03)的含量比较低.在女性中抽取总胆红素、直接胆红素和间接胆红素含量最高和最低的各25%,在校正了重要的变量后发现携带Trp/Trp基因型的女性比Gly460Gly基因型的女性有更大的可能性血清总胆红素含量(OR值=4.0; 95%可信区间: 1.6～10.2; P<0.01)、直接胆红素含量(OR值=4.0; 95%可信区间:1.6～9.7;P<0.01)和间接胆红素含量(OR值=2.7;95%可信区间: 1.1～6.7;P＝0.03)更低.然而,在男性高血压患者中没有发现任何明显的相关性.以上的结果认为在中国原发性高血压女性患者中,Trp/Trp基因型与低的血清胆红素含量有直接关系,因为Trp/Trp基因型的女性的低血清胆红素,进而认为也许增加了患心血管疾病的危险性.
探討瞭自2000年9月到2001年1月來自安徽省霍邱縣地區原髮性高血壓人群中α-Adducin基因單覈苷痠多態性與血清中總膽紅素、直接膽紅素和間接膽紅素含量的相關性.在原髮性高血壓女性患者中,在校正瞭許多可能影響膽紅素含量的重要因素後,與攜帶有Gly460Gly基因型的高血壓女性患者相比較,攜帶有Trp460Trp基因型的高血壓女性患者血清平均總膽紅素 (β= -1.2 μmol/L;P=0.01)、直接膽紅素(β= -0.4 μmol/L;P=0.02)和間接膽紅素(β= -0.8 μmol/L;P=0.03)的含量比較低.在女性中抽取總膽紅素、直接膽紅素和間接膽紅素含量最高和最低的各25%,在校正瞭重要的變量後髮現攜帶Trp/Trp基因型的女性比Gly460Gly基因型的女性有更大的可能性血清總膽紅素含量(OR值=4.0; 95%可信區間: 1.6～10.2; P<0.01)、直接膽紅素含量(OR值=4.0; 95%可信區間:1.6～9.7;P<0.01)和間接膽紅素含量(OR值=2.7;95%可信區間: 1.1～6.7;P＝0.03)更低.然而,在男性高血壓患者中沒有髮現任何明顯的相關性.以上的結果認為在中國原髮性高血壓女性患者中,Trp/Trp基因型與低的血清膽紅素含量有直接關繫,因為Trp/Trp基因型的女性的低血清膽紅素,進而認為也許增加瞭患心血管疾病的危險性.
탐토료자2000년9월도2001년1월래자안휘성곽구현지구원발성고혈압인군중α-Adducin기인단핵감산다태성여혈청중총담홍소、직접담홍소화간접담홍소함량적상관성.재원발성고혈압녀성환자중,재교정료허다가능영향담홍소함량적중요인소후,여휴대유Gly460Gly기인형적고혈압녀성환자상비교,휴대유Trp460Trp기인형적고혈압녀성환자혈청평균총담홍소 (β= -1.2 μmol/L;P=0.01)、직접담홍소(β= -0.4 μmol/L;P=0.02)화간접담홍소(β= -0.8 μmol/L;P=0.03)적함량비교저.재녀성중추취총담홍소、직접담홍소화간접담홍소함량최고화최저적각25%,재교정료중요적변량후발현휴대Trp/Trp기인형적녀성비Gly460Gly기인형적녀성유경대적가능성혈청총담홍소함량(OR치=4.0; 95%가신구간: 1.6～10.2; P<0.01)、직접담홍소함량(OR치=4.0; 95%가신구간:1.6～9.7;P<0.01)화간접담홍소함량(OR치=2.7;95%가신구간: 1.1～6.7;P＝0.03)경저.연이,재남성고혈압환자중몰유발현임하명현적상관성.이상적결과인위재중국원발성고혈압녀성환자중,Trp/Trp기인형여저적혈청담홍소함량유직접관계,인위Trp/Trp기인형적녀성적저혈청담홍소,진이인위야허증가료환심혈관질병적위험성.
We investigated associations of the Gly460Trp polymorphism of the α-adducin gene and concentrations of serum total bilirubin,serum direct bilirubin and serum unconjugated bilirubin in patients with essential hypertension from Anhui,China from September 2000 to January 2001.Compared to women with the Gly/Gly genotype and after adjustment for important covariates,women with the Trp/Trp genotype had lower mean concentrations of serum total bilirubin (β=-1.2 μmol/L;P=0.01),serum direct bilirubin (β=-0.4 μmol/L;P=0.02) and serum unconjugated bilirubin (β=-0.8 μmol/L;P=0.03).Among women in either the upper or lower quartiles of serum total bilirubin,serum direct bilirubin and serum unconjugated bilirubin and compared to those with the Gly/Gly genotype,women with the Trp/Trp genotype had higher odds of being in the lower quartile of concentrations of serum total bilirubin (odds ratio=4.0; 95 percent confidence interval:1.6～10.2;P<0.01),serum direct bilirubin (odds ratio=4.0;95 percent confidence: 1.6～9.7;P<0.01) and serum unconjugated bilirubin (odds ratio=2.7; 95 percent confidence interval: 1.1～6.7; P=0.03) after adjustment for important covariates.We did not observe any significant associations in these models for men.We concluded that the Trp/Trp genotype of α-adducin Gly460Trp was associated with lower serum bilirubin concentrations in this group of Chinese women with essential hypertension.Women with the Trp/Trp genotype of α-adducin Gly460Trp might have increased risk for cardiovascular diseases due to lower concentrations of serum bilirubin.
