CAJ | 학술논문

背景:注意缺陷多动障碍 (attention deficit hyperactivity disorder, ADHD)存在着强化机制的异常,而多动性是强化机制异常的一种表现.目的 :观察 ADHD动物模型自发高血压大鼠( SHR)的多动性变化,以探究其强化机制.设计:非随机对照的实验研究.地点、材料和干预:实验在挪威奥斯陆大学医学系生理实验室进行.实验选用 12只雄性 SHR大鼠和 12只雄性 Wistar Kyoto( WKY)大鼠.实验在标准 Campden连续反应测试箱中进行,大鼠禁水 22 h,采用长变异间期方案(变异指数 180 s),分析最后 10 d稳定曲线的均值.主要观察指标:大鼠按杠次数、推门次数及在不同阶段的变化.结果 :① SHR组大鼠按杠次数 [(642.9± 173.1)次 ]显著多于 WKY组 [(219.9± 79.5)次〗 (t=7.52, P《 0.01).②实验过程的 3个相同阶段 SHR大鼠的按杠次数比较,差异无显著性意义 (F=0.10, P 》0.05).③ SHR组的推门次数明显多于 WKY组 (t=4.43, P《 0.01),而获水次数与 WKY组比较,差异无显著性意义 (t=1.86, P 》0.05).结论: SHR大鼠的多动性较 WKY大鼠强,强化机制异常,有助于了解 ADHD的发病机制、临床治疗及预防.
배경:주의결함다동장애 (attention deficit hyperactivity disorder, ADHD)존재착강화궤제적이상,이다동성시강화궤제이상적일충표현.목적 :관찰 ADHD동물모형자발고혈압대서( SHR)적다동성변화,이탐구기강화궤제.설계:비수궤대조적실험연구.지점、재료화간예:실험재나위오사륙대학의학계생리실험실진행.실험선용 12지웅성 SHR대서화 12지웅성 Wistar Kyoto( WKY)대서.실험재표준 Campden련속반응측시상중진행,대서금수 22 h,채용장변이간기방안(변이지수 180 s),분석최후 10 d은정곡선적균치.주요관찰지표:대서안강차수、추문차수급재불동계단적변화.결과 :① SHR조대서안강차수 [(642.9± 173.1)차 ]현저다우 WKY조 [(219.9± 79.5)차〗 (t=7.52, P《 0.01).②실험과정적 3개상동계단 SHR대서적안강차수비교,차이무현저성의의 (F=0.10, P 》0.05).③ SHR조적추문차수명현다우 WKY조 (t=4.43, P《 0.01),이획수차수여 WKY조비교,차이무현저성의의 (t=1.86, P 》0.05).결론: SHR대서적다동성교 WKY대서강,강화궤제이상,유조우료해 ADHD적발병궤제、림상치료급예방.
BACKGROUND:Attention deficit hyperactivity disorder(ADHD) has abnormal strengthening mechanism and hyperactivity is one of the expressions of this abnormal strengthening mechanism. OBJECTIVE:To investigate the behavioral variations of spontaneous hypertensive rat(SHR),an ADHD animal model,for the exploration of its strengthening mechanism. DESIGN:A non-randomized controlled trial. SETTING,PARTICIPANTS and INTERVENTIONS:The study was conducted in the Laboratory of Physiology of the Faculty of Medicine of the University of Oslo,Norway.12 male SHR rats and 12 male Wistar Kyoto(WKY) rats were selected.The experiment was carried on in the standard Campden instrument operant chambers.The animals were water deprived for 22 hours.A long Variable Interval Schedule(variable index:180 s) was used to analyze the mean value of the stable curve of the last ten days. MAIN OUTCOME MEASURES:The times of lever-pressing and door-opening and the variation at different stages. CONCLUSION:The hyperactivity of SHR is much more obvious than that of the WKY and it has abnormal strengthening mechanism,which is helpful for the investigation of the pathogenesis and clinical therapy and prevention of ADHD.