CAJ | 학술논문

目的分析和对比医院2004-2006年产超广谱β-内酰胺酶(ESBLs)肺炎克雷伯菌的检出率和耐药情况.方法用VITEK-AMS微生物自动分析仪鉴定菌种和药物试验,同时对肺炎克雷伯菌进行ESBLs检测.结果产ESBLs肺炎克雷伯菌株检出率在2004、2005、2006年分别为20.5%、34.1%、41.9%,新生儿科连续3年产ESBLs检出率最高;未发现对亚胺培南耐药的菌株,产ESBLs菌株对第3代头孢菌素类、复方新诺明有极高耐药性,均高于非产ESBLs菌株.结论产ESBLs肺炎克雷伯菌株呈现逐年增加趋势,医生应慎重使用头孢菌素类抗生素,减少产ESBLs菌株的产生,防止其暴发与流行.
목적 분석화대비의원2004-2006년산초엄보β-내선알매(ESBLs)폐염극뢰백균적검출솔화내약정황.방법 용VITEK-AMS미생물자동분석의감정균충화약물시험,동시대폐염극뢰백균진행ESBLs검측.결과 산ESBLs폐염극뢰백균주검출솔재2004、2005、2006년분별위20.5%、34.1%、41.9%,신생인과련속3년산ESBLs검출솔최고;미발현대아알배남내약적균주,산ESBLs균주대제3대두포균소류、복방신낙명유겁고내약성,균고우비산ESBLs균주.결론 산ESBLs폐염극뢰백균주정현축년증가추세,의생응신중사용두포균소류항생소,감소산ESBLs균주적산생,방지기폭발여류행.
Objective To analyze and compare the detection rate and drug resistance of extended spectrum β lactamases (ESBLs)-producing K. pneumoniae strains in our hospital from 2004 to 2006.Methods VITEK-AMS microbial autoanalyzer was applied to identifying strain species and drug susceptibility test, while ESBLs test was carried out for the isolated K.pneunoniae strains.Results The detection rates for ESBLs-producing K.pneumoniae were 20.5%,34.1% and 41.9% in 2004, 2005 and 2006 respectively. Especially for Department of Newborns,the detection rate kept the highest over the three years.Imipenem-resistant strains weren't detected. ESBLs-producing strains were steeply resistant to the third generation cephalosporins and bactrim, much higher than non-ESBLs producing strains.Conclusion ESBLs-producing K.pneumoniae shows a tendency of increasing year by year. The cephem antibiotics should be used cautiously so as to reduce the heneration of ESBLs-producing K.pneumoniae strains and to prevent outbreak and prevalence of ESBLs producing K.pneumoniae infection.