CAJ | 학술논문

目的:考察中药化合物组释放动力学新理论在银翘解毒片释放特征评价中的适用性.方法:以Kalman滤波法为基础,进行紫外分光光度法测定银翘解毒片化合物组标准谱、线性、精密度、稳定性等方法学研究,测定银翘解毒片及其粉末的化合物组释放特征.结果:方法学结果表明,在0.112～1.120 mg生药/mL范围内银翘解毒片化合物组呈线性相关(r=0.999 7);高、中、低化合物组浓度测定的RSD分别为0.05%、0.07%和0.31%浓度分别为0.278,0.556,和1.120 mg生药/mL的供试液化合物组在24 h内稳定.结论:化合物组释放度能简洁、可视、直观地反映银翘解毒片多组分释放动力学特征,中药化合物组释放动力学新理论可以定量地揭示传统中药制剂的新内涵或其给药系统的活性组分释放特征.
목적:고찰중약화합물조석방동역학신이론재은교해독편석방특정평개중적괄용성.방법:이Kalman려파법위기출,진행자외분광광도법측정은교해독편화합물조표준보、선성、정밀도、은정성등방법학연구,측정은교해독편급기분말적화합물조석방특정.결과:방법학결과표명,재0.112～1.120 mg생약/mL범위내은교해독편화합물조정선성상관(r=0.999 7);고、중、저화합물조농도측정적RSD분별위0.05%、0.07%화0.31%농도분별위0.278,0.556,화1.120 mg생약/mL적공시액화합물조재24 h내은정.결론:화합물조석방도능간길、가시、직관지반영은교해독편다조분석방동역학특정,중약화합물조석방동역학신이론가이정량지게시전통중약제제적신내함혹기급약계통적활성조분석방특정.
AIM: To verify the applicability of a new theory for chemomic release kinetics of traditional Chinese medicines using the release characteristics of Yinqiaojiedu tablets.METHOD: The methodological studies of the preparation of chemomic standard spectrum, linearity, precision and stability tests of the chemomes of Yinqiaojiedu tablets were processed by UV spectrophotometry and Kalman filter methods.The chemomic release profiles of Yinqiaojiedu tablets and powders were determined.RESULT: The methodology studies indicated that there was a good linearity of chemomic concentration of Yinqiaojiedu tablets within the range 0.112 to 1.120 mg total herbs / mL (r=0.999 7).The values of RSD tested at three chemomic levels were 0.05 %, 0.07 % and 0.31% respectively.The chemomic solutions were stable for 24 h at concentrations of 0.278, 0.556, and 1.120 mg total herb / mL.CONCLUSION:The chemomic release profiles demonstrated multi-component release kinetics illustrated using a simple visualization approach.The new theory of chemomic release kinetics may advantageously provide a quantitative description for the release of the active agents from traditional Chinese medicines from a conventional dosage form or drug delivery system.[KEY WORDS] Chemome; Chemomic release kinetics; Kalman filtering method; Multi-component; Yinqiaojiedu tablets