国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2009年
9期
843-844,847
,共3页
冠状动脉疾病%血管成形术%经腔%经皮冠状动脉%内皮缩血管肽类%6-酮-前列腺素F1α
冠狀動脈疾病%血管成形術%經腔%經皮冠狀動脈%內皮縮血管肽類%6-酮-前列腺素F1α
관상동맥질병%혈관성형술%경강%경피관상동맥%내피축혈관태류%6-동-전렬선소F1α
Coronary disease%Angioplasty%transluminal%percutaneous coronary%Endothe-lins%6-Ketoprostaglandin F1 alpha
目的 探讨血管活性物质血浆内皮素(ET)、血栓素B2(TXB2)、6-酮-前列腺素F1α(6-keto-PGF1α)与再狭窄的变化规律.方法 用放射免疫法测定41例冠心病患者术前及术后30 min、1d、3 d的血浆ET、TXBz、6-keto-PGF1α的浓度.结果 PTCA术后血浆ET水平30 min较术前显著降低(P<0.05),术后1、3 d与术前差异无统计学意义(P>0.05);术后血浆TXB2水平30 min、1 d及3d与术前比较差异无统计学意义(P>0.05),术后血浆6-keto-PGF1α水平30 min较术前显著降低(P<0.05),术后1、3 d与术前比较差异无统计学意义(P>0.05).结论 PTCA术后可引起冠状动脉循环ET、TXB2、6-keto-PGF1α的波动,研究这些血管活性物质的变化规律,对PTCA急性闭塞和远期再狭窄的预防有重要的意义.
目的 探討血管活性物質血漿內皮素(ET)、血栓素B2(TXB2)、6-酮-前列腺素F1α(6-keto-PGF1α)與再狹窄的變化規律.方法 用放射免疫法測定41例冠心病患者術前及術後30 min、1d、3 d的血漿ET、TXBz、6-keto-PGF1α的濃度.結果 PTCA術後血漿ET水平30 min較術前顯著降低(P<0.05),術後1、3 d與術前差異無統計學意義(P>0.05);術後血漿TXB2水平30 min、1 d及3d與術前比較差異無統計學意義(P>0.05),術後血漿6-keto-PGF1α水平30 min較術前顯著降低(P<0.05),術後1、3 d與術前比較差異無統計學意義(P>0.05).結論 PTCA術後可引起冠狀動脈循環ET、TXB2、6-keto-PGF1α的波動,研究這些血管活性物質的變化規律,對PTCA急性閉塞和遠期再狹窄的預防有重要的意義.
목적 탐토혈관활성물질혈장내피소(ET)、혈전소B2(TXB2)、6-동-전렬선소F1α(6-keto-PGF1α)여재협착적변화규률.방법 용방사면역법측정41례관심병환자술전급술후30 min、1d、3 d적혈장ET、TXBz、6-keto-PGF1α적농도.결과 PTCA술후혈장ET수평30 min교술전현저강저(P<0.05),술후1、3 d여술전차이무통계학의의(P>0.05);술후혈장TXB2수평30 min、1 d급3d여술전비교차이무통계학의의(P>0.05),술후혈장6-keto-PGF1α수평30 min교술전현저강저(P<0.05),술후1、3 d여술전비교차이무통계학의의(P>0.05).결론 PTCA술후가인기관상동맥순배ET、TXB2、6-keto-PGF1α적파동,연구저사혈관활성물질적변화규률,대PTCA급성폐새화원기재협착적예방유중요적의의.
Objective To explore the regularity of changes of plasma endothelin (ET), throm-boxame B2(TXB2) and 6-keto-prostaglandin F1α(6-keto-PGF1α) and restenosis after percutaneous transluminal angioplasty (PTCA) in patients with coronary heart disease. Methods Radioimmunoas-say was applied to measuring plasma levels of ET, TXB2and 6-keto-PGF1αat 0,30 min, 1 day and 3 days after PTCA in 41 patients with coronary heart disease. Results The level of ET in the patients with coronary heart disease was significantly decreased in 30 minutes after PTCA (P＜0.05), but no significant difference was observed in 1 day and 3 days after PTCA (P>0.05). The level of plasma TXB2has no statistical difference after PTCA in 30minutes, 1 day and 3 days (P>0.05). The level of 6-keto-prostaglandin F1α(6-keto-PGF1α) of the patients with coronary heart disease was significantly declined in 30 minutes after PTCA (P<0.05) ,but no significant difference was observed in 1 day and 3 days after PTCA (P>0.05). Conclusion PTCA may lead to fluctuation of plasma levels of ET, TXB2and 6-keto-PGF1αThe clarification of changing regularity of these vasoactive substances contrib-utes to prevention of acute artery occlusion or restenosis after PTCA.
