CAJ | 학술논문

纳米药物晶体可解决多数难溶性药物的溶解度和溶出度问题,近年来成为难溶性药物给药系统研究的热点之一.本文着重综述了纳米药物晶体的制备技术,如沉淀法、分散法、乳化法和微乳化法、超临界流体结晶法等的研究进展.
납미약물정체가해결다수난용성약물적용해도화용출도문제,근년래성위난용성약물급약계통연구적열점지일.본문착중종술료납미약물정체적제비기술,여침정법、분산법、유화법화미유화법、초림계류체결정법등적연구진전.
The solubility and dissolution problems of the majority of the slightly soluble drugs Can be improved by preparing drug nanocrystals.Therefore drug nanocrystals have become one of the focal points of drug delivery systems.Based on recent literatures at home and abroad,this paper emphasizes on the progress of the preparation techniques of drug nanocrystals,such as precipitation method,dispersion method,emulsification and microemulsification, supercritical fluid crystallization,etc.