CAJ | 학술논문

目的探讨血清一氧化氮(nitric oxide,NO)、一氧化氮合酶(nitric oxide synthsae,NOS)的水平及其动态变化与急性一氧化碳中毒后迟发性脑病(delayed encephalopathy after acute carbon monoxide poisoning,DEACMP)患者病情变化的关系.方法应用比色法(colorimetric method)动态测定31例DEACMP患者血清NO及NOS水平,并与30例急性一氧化碳中毒(acute carbon monoxide poisoning,ACMP)后未发生迟发脑病患者和30 例正常对照进行比较.结果 DEACMP患者急性期血清NO及NOS水平[(62.67 ± 14.39)μmol/L,(27.68 ± 6.14)U/mL]明显高于正常对照组[(50.18 ± 9.95) μmol/L,(20.88 ± 6.32)U/mL] (均P ＜ 0.05),与ACMP组急性期[(62.00 ± 16.46)μmol/L,(28.13 ± 5.23)U/mL]比较无统计学差异(均P ＞ 0.05);DEACMP患者恢复期血清NO及NOS水平[(54.66 ± 11.73)μmol/L,(21.74 ± 5.88)U/mL]明显低于急性期(均P ＜ 0.05),与ACMP组随访期[(52.79 ± 11.22)μmol/L,(20.64 ± 5.92)U/mL]比较无统计学差异(均P ＞ 0.05).结论 NO-NOS系统参与了DEACMP的发病机制,NO-NOS水平变化与病情变化基本一致.
목적 탐토혈청일양화담(nitric oxide,NO)、일양화담합매(nitric oxide synthsae,NOS)적수평급기동태변화여급성일양화탄중독후지발성뇌병(delayed encephalopathy after acute carbon monoxide poisoning,DEACMP)환자병정변화적관계.방법 응용비색법(colorimetric method)동태측정31례DEACMP환자혈청NO급NOS수평,병여30례급성일양화탄중독(acute carbon monoxide poisoning,ACMP)후미발생지발뇌병환자화30 례정상대조진행비교.결과 DEACMP환자급성기혈청NO급NOS수평[(62.67 ± 14.39)μmol/L,(27.68 ± 6.14)U/mL]명현고우정상대조조[(50.18 ± 9.95) μmol/L,(20.88 ± 6.32)U/mL] (균P ＜ 0.05),여ACMP조급성기[(62.00 ± 16.46)μmol/L,(28.13 ± 5.23)U/mL]비교무통계학차이(균P ＞ 0.05);DEACMP환자회복기혈청NO급NOS수평[(54.66 ± 11.73)μmol/L,(21.74 ± 5.88)U/mL]명현저우급성기(균P ＜ 0.05),여ACMP조수방기[(52.79 ± 11.22)μmol/L,(20.64 ± 5.92)U/mL]비교무통계학차이(균P ＞ 0.05).결론 NO-NOS계통삼여료DEACMP적발병궤제,NO-NOS수평변화여병정변화기본일치.