CAJ | 학술논문

自噬是细胞内蛋白、细胞器降解的渐变过程.目前,自噬性细胞死亡被认为是第Ⅱ类程序化细胞死亡.对肿瘤细胞自噬的抑制可导致不同的结果--生存或死亡,因此自噬是细胞死亡机制还是细胞保护机制存在争议.总的来说,对自噬的利用可推动新的肿瘤治疗方法的进展.
자서시세포내단백、세포기강해적점변과정.목전,자서성세포사망피인위시제Ⅱ류정서화세포사망.대종류세포자서적억제가도치불동적결과--생존혹사망,인차자서시세포사망궤제환시세포보호궤제존재쟁의.총적래설,대자서적이용가추동신적종류치료방법적진전.
Autophagy is an evolutionarily conserved lysosomal pathway for the degradation of cytoplasmic proteins,macromolecules,and organelles.Now,autophagic cell death is considered as programmed cell death type Ⅱ.In multiple studies,inhibition of autophagy will result in contrasting outcomes-survival or death.Thus,whether autophagy in cancer cells causes death or protects cells is controversial.Taken together,the manipulation of autophagy may lead to development of new cancer therapies.This article focuses on recent progresses of autophagy research related to human cancers therapy.