中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2008年
2期
212-214
,共3页
前列腺增生%下尿路综合征%托特罗定%坦索罗辛
前列腺增生%下尿路綜閤徵%託特囉定%坦索囉辛
전렬선증생%하뇨로종합정%탁특라정%탄색라신
Prostatic hyperplasia%Low urinary tract syndrome%Tolterodine%Tamsulosin
目的 观察托特罗定合用坦索罗辛对大鼠实验性良性前列腺增生致下尿路功能紊乱的改善作用.方法 健康雄性SD大鼠去势后,丙酸睾丸酮皮下注射制作前列腺增生模型.模型大鼠分别灌胃给予托特罗定(0.4 mg/kg),坦索罗辛(0.04 mg/kg)或托特罗定+坦索罗辛[(0.4+0.04)mg/kg]14 d,给药后测定前列腺指数,生理记录仪记录大鼠排尿波后采集排尿时间、排尿间隔时间、排尿点压、排尿压峰值等指标,并记录残余尿量和膀胱容积,观察药物对上述指标的改善作用.结果 托特罗定合用坦索罗辛可全面改善良性前列腺增生大鼠的排尿时间、排尿间隔时间、排尿点压和排尿压峰值,能够同时改善大鼠的尿频及排尿困难症状,并减少大鼠残余尿量(P＜0.05或P＜0.01).两药合用对膀胱容积无明显影响.结论 托特罗定合用坦索罗辛在有效减轻良性前列腺增生大鼠下尿路梗阻症状的同时,可有效降低其膀胱兴奋性,未增加良性前列腺增生大鼠的尿潴留危险,为临床治疗同时伴有梗阻和膀胱过度活动症状的前列腺增生患者提供了新的选择.
目的 觀察託特囉定閤用坦索囉辛對大鼠實驗性良性前列腺增生緻下尿路功能紊亂的改善作用.方法 健康雄性SD大鼠去勢後,丙痠睪汍酮皮下註射製作前列腺增生模型.模型大鼠分彆灌胃給予託特囉定(0.4 mg/kg),坦索囉辛(0.04 mg/kg)或託特囉定+坦索囉辛[(0.4+0.04)mg/kg]14 d,給藥後測定前列腺指數,生理記錄儀記錄大鼠排尿波後採集排尿時間、排尿間隔時間、排尿點壓、排尿壓峰值等指標,併記錄殘餘尿量和膀胱容積,觀察藥物對上述指標的改善作用.結果 託特囉定閤用坦索囉辛可全麵改善良性前列腺增生大鼠的排尿時間、排尿間隔時間、排尿點壓和排尿壓峰值,能夠同時改善大鼠的尿頻及排尿睏難癥狀,併減少大鼠殘餘尿量(P＜0.05或P＜0.01).兩藥閤用對膀胱容積無明顯影響.結論 託特囉定閤用坦索囉辛在有效減輕良性前列腺增生大鼠下尿路梗阻癥狀的同時,可有效降低其膀胱興奮性,未增加良性前列腺增生大鼠的尿潴留危險,為臨床治療同時伴有梗阻和膀胱過度活動癥狀的前列腺增生患者提供瞭新的選擇.
목적 관찰탁특라정합용탄색라신대대서실험성량성전렬선증생치하뇨로공능문란적개선작용.방법 건강웅성SD대서거세후,병산고환동피하주사제작전렬선증생모형.모형대서분별관위급여탁특라정(0.4 mg/kg),탄색라신(0.04 mg/kg)혹탁특라정+탄색라신[(0.4+0.04)mg/kg]14 d,급약후측정전렬선지수,생리기록의기록대서배뇨파후채집배뇨시간、배뇨간격시간、배뇨점압、배뇨압봉치등지표,병기록잔여뇨량화방광용적,관찰약물대상술지표적개선작용.결과 탁특라정합용탄색라신가전면개선량성전렬선증생대서적배뇨시간、배뇨간격시간、배뇨점압화배뇨압봉치,능구동시개선대서적뇨빈급배뇨곤난증상,병감소대서잔여뇨량(P＜0.05혹P＜0.01).량약합용대방광용적무명현영향.결론 탁특라정합용탄색라신재유효감경량성전렬선증생대서하뇨로경조증상적동시,가유효강저기방광흥강성,미증가량성전렬선증생대서적뇨저류위험,위림상치료동시반유경조화방광과도활동증상적전렬선증생환자제공료신적선택.
Objective To investigate the efficacy of tolterodine plus tamsulosin in rats with benign prostatic hyperplasia(BPH)induced low urinary tract syndrome(LUTS).Methods Male rats were castrated,then testosterone propionate were given by subcutaneous injection to induce BPH/LUTS model.Model rats were intragastrically administrated with 0.4mg/kg of tolterodine,0.04mg/kg of tamsulosin or(0.4+0.04)mg/kg of tolterodine plus tamsulosin for 14 days and urodynamics,residual urine volume and volume of bladder were mearsured.Results Tolterodine plus tamsulosin could simultaneously shorten the micturition duration,prolong the interval duration between micturition,decrease the threshold intravesical pressure at micturition and the max intravesical Pressure at micturition significantly.The combined-therapy method could also decrease the residual urine volume to a certein extent and had no obvious influence on enlarging the volume of bladder(P＜0.05 or P＜0.01).Conclusion Combination treatment with tolterodine and tamsulosin may efficiently ameliorate bladder outlet obstrution and overactive bladder simultaneously,with no extra danger of uroschesis.
