CAJ | 학술논문

目的探讨肿瘤靶向治疗药物恩度联合放化疗治疗初诊晚期非小细胞肺癌的优势,寻找一种治疗晚期非小细胞肺癌有效的治疗组合模式,提高晚期肺癌患者的生存率及生存质量.方法将2009年7月至2010年2月收住的18例初诊为晚期非小细胞肺癌患者随机分为实验组(含恩度)和对照组(不含恩度)各9例,采用诱导化疗并三维适形放疗,观察2组患者治疗的临床症状缓解率、疗效、不良反应,同时做好放化疗及靶向治疗的护理.结果实验组及对照组的疗效分别为77.8%和66.7%,实验组的临床症状缓解率与对照组比较无显著差异,2组患者均有不同程度的不良反应,在护理人员的整体护理和系统健康教育下,均顺利完成治疗.结论恩度联合放化疗治疗初诊晚期非小细胞肺癌,能提高疗效及生存率,改善生活质量,虽有一定的不良反应,但经对症处理及护理能缓解.
목적 탐토종류파향치료약물은도연합방화료치료초진만기비소세포폐암적우세,심조일충치료만기비소세포폐암유효적치료조합모식,제고만기폐암환자적생존솔급생존질량.방법 장2009년7월지2010년2월수주적18례초진위만기비소세포폐암환자수궤분위실험조(함은도)화대조조(불함은도)각9례,채용유도화료병삼유괄형방료,관찰2조환자치료적림상증상완해솔、료효、불량반응,동시주호방화료급파향치료적호리.결과 실험조급대조조적료효분별위77.8%화66.7%,실험조적림상증상완해솔여대조조비교무현저차이,2조환자균유불동정도적불량반응,재호리인원적정체호리화계통건강교육하,균순리완성치료.결론 은도연합방화료치료초진만기비소세포폐암,능제고료효급생존솔,개선생활질량,수유일정적불량반응,단경대증처리급호리능완해.
Objective To study in targeted therapy of cancer drug endostar combined with radiotherapy and chemotherapy in the treatment of newly diagnosed patients with advanced non-small cell lung cancer, and find an effective combined treatment mode of advanced non-small cell lung cancer, so as to improve the survival rate and quality of life of patients with advanced lung cancer. Methods 18 patients with newly diagnosed advanced non- small cell lung cancer admitted to our hospital from July 2009 to February 2010 were randomly divided into 2 groups and treated with induction chemotherapy and 3D-CRT,9 cases in the experimental group (including Endostar), 9 cases in the control group, All of the patients'clinical symptoms, efficacy and toxicity in the two groups were observed. At the same time, nursing of radiotherapy, chemotherapy and targeted therapy was given to paients. Results The efficacy of the experimental group and the control group were 77.8% and 66.7%, the clinical remission rates of the experimental group and the control group showed no significant difference, both of the patients in the two groups had varying degrees of toxicity, but all of the them completed the treatment well under the holistic nursing and systematical health education by nurses. Conclusions Endostar combined with induction chemotherapy and three-dimensional conformal radiotherapy (3D-CRT) in the treatment of advanced non-small cell lung cancer can improve the efficacy and survival rate, and the quality of life, although there are some side effects, but can be alleviated by symptomatic treatment and care.