中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2012年
6期
610-613
,共4页
周雁%郭立新%于冬妮%周璐%汪耀%牟忠卿%王晓霞%张丽娜%李铭
週雁%郭立新%于鼕妮%週璐%汪耀%牟忠卿%王曉霞%張麗娜%李銘
주안%곽립신%우동니%주로%왕요%모충경%왕효하%장려나%리명
2型糖尿病%糖尿病肾病%相关因素
2型糖尿病%糖尿病腎病%相關因素
2형당뇨병%당뇨병신병%상관인소
Diabetes melhtus,type 2%Diabetic nephropathy%Relative factors
目的 探讨2型糖尿病患者糖尿病肾病(DN)相关因素.方法 采用回顾性分析方法选取2003-2010年卫生部北京医院住院治疗的1758例2型糖尿病患者,按尿微量白蛋白排泄率(UAER)结果分为三组,UAER＜20 μg/min为无糖尿病肾病组(NA),20～ 200 μg/min为DN微量白蛋白组(MA),≥200 μg/min为DN大量白蛋白尿组(LA).对患者的临床数据进行比较,用多因素logistic回归探寻DN的相关因素.结果 (1)1758例2型糖尿病患者中NA组1246例,MA组408例,LA组104例,DN构成比为29.1％.(2)NA、MA、LA组患者年龄分别为(59.87±12.77、62.52±12.74、64.44±12.74)岁,体重指数(BMI)分别为(24.90±3.42、25.53±4.00、25.53±3.91 )kg/m2,糖尿病病程分别为(8.39±7.12、10.77±8.02、12.84±7.97)年,收缩压(SBP)分别为(133.42±18.19、142.72±20.21、151.12±21.91 )mm Hg,舒张压分别为(78.75±10.66、80.79±12.21、83.33±13.61 )mm Hg,空腹血糖(FBS)分别为(8.25±3.43、9.02±3.72、9.22±4.62)mmol/L,糖化血红蛋白(HbAlc)分别为(8.88±2.10、9.34±2.36、9.10±2.36)％,尿酸(UA)分别为(288.04±90.41、307.23±96.96、374.28±105.47) mmol/L,甘油三酯分别为(1.72±1.51、2.06±1.88、1.94±1.42)mmol/L,高密度脂蛋白胆固醇分别为(1.08±0.30、1.02±0.29、1.07±0.28) mmol/L、空腹胰岛素水平分别为( 9.24±9.02、11.24±9.74、11.06±9.29) μU/ml,空腹C肽分别为(462.31±289.94、510.02±350.08、595.93±445.86) pmol/L,上述指标3组间差异有统计学意义(P＜0.05或P＜0.01).(3)logistic回归分析显示,DN与糖尿病病程、BMI、SBP、HbAlc、FBS、UA有关(OR值分别为1.041、1.055、1.028、1.116、1.100.1.004,P＜0.05或P＜0.01).结论 2型糖尿病患者应综合控制体重、血压、血糖和UA水平,有助于防治DN.
目的 探討2型糖尿病患者糖尿病腎病(DN)相關因素.方法 採用迴顧性分析方法選取2003-2010年衛生部北京醫院住院治療的1758例2型糖尿病患者,按尿微量白蛋白排洩率(UAER)結果分為三組,UAER＜20 μg/min為無糖尿病腎病組(NA),20～ 200 μg/min為DN微量白蛋白組(MA),≥200 μg/min為DN大量白蛋白尿組(LA).對患者的臨床數據進行比較,用多因素logistic迴歸探尋DN的相關因素.結果 (1)1758例2型糖尿病患者中NA組1246例,MA組408例,LA組104例,DN構成比為29.1％.(2)NA、MA、LA組患者年齡分彆為(59.87±12.77、62.52±12.74、64.44±12.74)歲,體重指數(BMI)分彆為(24.90±3.42、25.53±4.00、25.53±3.91 )kg/m2,糖尿病病程分彆為(8.39±7.12、10.77±8.02、12.84±7.97)年,收縮壓(SBP)分彆為(133.42±18.19、142.72±20.21、151.12±21.91 )mm Hg,舒張壓分彆為(78.75±10.66、80.79±12.21、83.33±13.61 )mm Hg,空腹血糖(FBS)分彆為(8.25±3.43、9.02±3.72、9.22±4.62)mmol/L,糖化血紅蛋白(HbAlc)分彆為(8.88±2.10、9.34±2.36、9.10±2.36)％,尿痠(UA)分彆為(288.04±90.41、307.23±96.96、374.28±105.47) mmol/L,甘油三酯分彆為(1.72±1.51、2.06±1.88、1.94±1.42)mmol/L,高密度脂蛋白膽固醇分彆為(1.08±0.30、1.02±0.29、1.07±0.28) mmol/L、空腹胰島素水平分彆為( 9.24±9.02、11.24±9.74、11.06±9.29) μU/ml,空腹C肽分彆為(462.31±289.94、510.02±350.08、595.93±445.86) pmol/L,上述指標3組間差異有統計學意義(P＜0.05或P＜0.01).(3)logistic迴歸分析顯示,DN與糖尿病病程、BMI、SBP、HbAlc、FBS、UA有關(OR值分彆為1.041、1.055、1.028、1.116、1.100.1.004,P＜0.05或P＜0.01).結論 2型糖尿病患者應綜閤控製體重、血壓、血糖和UA水平,有助于防治DN.
목적 탐토2형당뇨병환자당뇨병신병(DN)상관인소.방법 채용회고성분석방법선취2003-2010년위생부북경의원주원치료적1758례2형당뇨병환자,안뇨미량백단백배설솔(UAER)결과분위삼조,UAER＜20 μg/min위무당뇨병신병조(NA),20～ 200 μg/min위DN미량백단백조(MA),≥200 μg/min위DN대량백단백뇨조(LA).대환자적림상수거진행비교,용다인소logistic회귀탐심DN적상관인소.결과 (1)1758례2형당뇨병환자중NA조1246례,MA조408례,LA조104례,DN구성비위29.1％.(2)NA、MA、LA조환자년령분별위(59.87±12.77、62.52±12.74、64.44±12.74)세,체중지수(BMI)분별위(24.90±3.42、25.53±4.00、25.53±3.91 )kg/m2,당뇨병병정분별위(8.39±7.12、10.77±8.02、12.84±7.97)년,수축압(SBP)분별위(133.42±18.19、142.72±20.21、151.12±21.91 )mm Hg,서장압분별위(78.75±10.66、80.79±12.21、83.33±13.61 )mm Hg,공복혈당(FBS)분별위(8.25±3.43、9.02±3.72、9.22±4.62)mmol/L,당화혈홍단백(HbAlc)분별위(8.88±2.10、9.34±2.36、9.10±2.36)％,뇨산(UA)분별위(288.04±90.41、307.23±96.96、374.28±105.47) mmol/L,감유삼지분별위(1.72±1.51、2.06±1.88、1.94±1.42)mmol/L,고밀도지단백담고순분별위(1.08±0.30、1.02±0.29、1.07±0.28) mmol/L、공복이도소수평분별위( 9.24±9.02、11.24±9.74、11.06±9.29) μU/ml,공복C태분별위(462.31±289.94、510.02±350.08、595.93±445.86) pmol/L,상술지표3조간차이유통계학의의(P＜0.05혹P＜0.01).(3)logistic회귀분석현시,DN여당뇨병병정、BMI、SBP、HbAlc、FBS、UA유관(OR치분별위1.041、1.055、1.028、1.116、1.100.1.004,P＜0.05혹P＜0.01).결론 2형당뇨병환자응종합공제체중、혈압、혈당화UA수평,유조우방치DN.
Objective To analyze the prevalence rate of diabetic nephropathy (DN) and the related factors on DN among type 2 diabetic patients.Methods A total number of 1758 type 2 diabetic patients who were hospitalized in the Beijing Hospital from 2003 to 2010 were analyzed retrospectively.Three groups were divided according to the rate of urinary albumin excretion (UAER).Patients whose UAER＜20 μg/min belonged to normal albuminuria (NA) group.The ones whose UAER from 20 to 200 μ g/min belonged to microalbuminuria (MA) group,and the others whose UAER≥200 μg/min belonged to large albuminuia (LA) group.The clinical characteristics were then compared.The related factors of DN were analyzed.Results (1)There were 1246 patients in NA group,408 patients in MA group,and 104 patients in LA group.The constituent ratio of nephropathy was 29.1％ (2) The ages of NA group,MA group and LA group were (59.87± 12.77,62.52± 12.74,64.44 ± 12.74) years old,respectively,with body mass index ( BMI ) as (24.90 ± 3.42,25.53 ± 4.00,25.53 ± 3.91 )kg/m2 respectively; duration of diabetes as (8.39 ± 7.12,10.77 ± 8.02,12.84 ± 7.97)years; systolic blood pressure (SBP) as (133.42 ± 18.19,142.72 ± 20.21,151.12 ± 21.91 )mm Hg;diastolic blood pressure as (78.75 ± 10.66,80.79 ±12.21,83.33 ±13.61 )mm Hg; fasting blood suger (FBS) as (8.25±3.43,9.02±3.72,9.22±4.62)mmol/L; glycated hemoglobin(HbAlc) as (8.88±2.10,9.34 ± 2.36,9.10 ± 2.36)％ ; uric acid (UA) as (288.04 ± 90.41,307.23 ± 96.96,374.28 ±105.47) mmol/L; triglyceride as (1.72 ± 1.51,2.06 ± 1.88,1.94 ± 1.42) mmol/L,high density lipoprotein cholesterol as ( 1.08 ± 0.30,1.02 ± 0.29,1.07 ± 0.28) mmol/L; fasting insulin as (9.24 ±9.02,11.24 ± 9.74,11.06 ± 9.29) μU/ml; fasting C peptide as (462.31 ± 289.94,510.02 ± 350.08,595.93 ± 445.86) pmol/L.There were significant differences between NA,MA and LA groups in all above items ( P ＜ 0.01 or P＜ 0.05 ).( 3 ) Logistic regression analysis showed that DN were related with duration of diabetes,BMI,SBP,HbAlc,FBS,UA (OR values were 1.041,1.055,1.028,1.116,1.100,1.004 respectively,P＜0.05 or P＜0.01 ).Conclusion It would be helpful to prevent and retard progression of DN that comprehensively controlling high blood glucose,hypertension,hyperuricemia and body weight of type 2 diabetic patients.
