CAJ | 학술논문

结核病是发展中国家常见的疾病,病死率高.众多研究表明,全球约有1/3的人群感染过结核分枝杆菌,但仅有5%～10%的感染个体最终发展为临床结核,说明结核病的发生发展存在着遗传易感性.细胞因子是结核病免疫的重要组成部分,细胞因子的基因多态性影响着细胞因子的水平,而且与疾病的结局存在相关性.本文就结核病中重要的细胞因子的基因多态性与结核遗传易感性的关系作一综述.
결핵병시발전중국가상견적질병,병사솔고.음다연구표명,전구약유1/3적인군감염과결핵분지간균,단부유5%～10%적감염개체최종발전위림상결핵,설명결핵병적발생발전존재착유전역감성.세포인자시결핵병면역적중요조성부분,세포인자적기인다태성영향착세포인자적수평,이차여질병적결국존재상관성.본문취결핵병중중요적세포인자적기인다태성여결핵유전역감성적관계작일종술.
Tuberculosis is a common disease in developing countries,its mortality is high. Many studies show that one third of people in the world is infected by Mycobacterium tuberculosis, but only 5 %-10% of the infected people eventually develop clinical tuberculosis, which indicates that genetic susceptibility plays an important role in the development of tuberculosis. Cytokines are significant ingredients in tuberculosis immunity. Cytokine gene polymorphisms influence cytokine levels and may be associated with outcome of the disease. This review summarizes the relationship between gene polymorphisms of the important cytokine and geretic susceptibility to tuberculosis.