CAJ | 학술논문

目的探讨肝内胆管癌的诊治方法和预后相关因素.方法回顾性分析本院1995年1月～2005年12月手术治疗的86例肝内胆管癌的临床资料,根据不同治疗方法分为两组:肝切除加肝十二脂肠韧带淋巴结常规清扫组(A组)42例,单纯肝切除组(B组)44例,对临床病理因素进行了对比分析.结果 A组1、3和5年生存率分别为77.81%、35.21%和20.93%;B组1、3和5年生存率分别为19.82%、2.31%和0%.2组差异有统计学意义(P<0.01).手术切除加淋巴结清扫与预后显著相关,47例淋巴结阴性组1、3和5年生存率分别为59.21%、26.21%和20.11%;39例淋巴结阳性组1、3和5年生存率分别为50.21%、11.21%和0%,2组比较差异有统计学意叉(P<0.01).结论淋巴结转移和手术切除是影响生存的主要因素,对肝十二指肠韧带淋巴结转移预防性清扫和积极治疗,可延长肝内胆管癌病人的生存率,提高了生活质量.
목적 탐토간내담관암적진치방법화예후상관인소.방법 회고성분석본원1995년1월～2005년12월수술치료적86례간내담관암적림상자료,근거불동치료방법분위량조:간절제가간십이지장인대림파결상규청소조(A조)42례,단순간절제조(B조)44례,대림상병리인소진행료대비분석.결과 A조1、3화5년생존솔분별위77.81%、35.21%화20.93%;B조1、3화5년생존솔분별위19.82%、2.31%화0%.2조차이유통계학의의(P<0.01).수술절제가림파결청소여예후현저상관,47례림파결음성조1、3화5년생존솔분별위59.21%、26.21%화20.11%;39례림파결양성조1、3화5년생존솔분별위50.21%、11.21%화0%,2조비교차이유통계학의차(P<0.01).결론 림파결전이화수술절제시영향생존적주요인소,대간십이지장인대림파결전이예방성청소화적겁치료,가연장간내담관암병인적생존솔,제고료생활질량.
Objective To investigate the approaches for diagnosis and treatment of intrahepatic cholangiocarcinoma(ICC)and asgess its prognosis factors.Methods The clinical data of 86 patients with ICC in our hospital from January 1995 to December2005 were retrospeetively analyzed.All patients were divided into two groups according to the treatment method,including hepatectomy and lymphatic clearance group(Group A,n=42)and hepateetomy group(Group B,n=44),and their clinicopathological variables were analyzed.Resuits The 1-,3-and 5-year survival rates were 77.81%and 35.21%,20.93%and 19.82%,2.31%and 0%respectively between group A and group B.There was significantly difference between these two groups(P＜0.01).The analysis showed that resection and lymphatic clearance were correlated to prognosis.The 1-,3-and 5-year survival rates were 59.21%,26.21%,and 20.11% respectively in 47 patients who were found no lymph node metastasis,and the 1-,3-and 5-year survival rates were 19.82%,2.31%and 0% respectively in 39 patients who were found lymph node metastasis.There was significantly difference in survival rate between group A and group B(P＜0.01).Condusions Reseetability and lymphatic clearance are two significant factors correlated to survival of the patients with ICC.Aggresgive treatment of lymph node metastasis in hepatoduodenal ligament is an important strategy to improve survival rates and strengthen patient's life quality.