CAJ | 학술논문

目的研究血清维生素D水平在2型糖尿病发病过程中的作用.方法采用随机分层抽样,共589例志愿者纳入本研究.根据空腹血糖及口服葡萄糖耐量试验结果将志愿者区分为糖尿病人群及非糖尿病人群.共计249例检测了血清25-羟维生素D水平,应用二元Logistic回归分析糖尿病与相关因素的关系,应用Cox-Staurt趋势检验分析各年龄段血清25-羟维生素D水平,按血清25(OH)D四分位值分层,分别计算糖尿病患病优势比OR值及95％置信区间.结果所有年龄段均存在不同程度的25-羟维生素D缺乏,调节年龄、HOMA-IR、BMI后,血清25-羟维生素D水平与糖尿病发病呈剂量依赖的负相关(r=-0.9271,P＜0.01),当血清25-羟维生素D水平达到94.6nmol/L以上时,糖尿病发病显著降低[OR =0.52,95％CI(0.23～0.78),P＜0.01].结论血清25-羟维生素D水平与2型糖尿病发病呈明显负相关,血清25-羟维生素D水平降低增加糖尿病发病风险.
목적 연구혈청유생소D수평재2형당뇨병발병과정중적작용.방법 채용수궤분층추양,공589례지원자납입본연구.근거공복혈당급구복포도당내량시험결과장지원자구분위당뇨병인군급비당뇨병인군.공계249례검측료혈청25-간유생소D수평,응용이원Logistic회귀분석당뇨병여상관인소적관계,응용Cox-Staurt추세검험분석각년령단혈청25-간유생소D수평,안혈청25(OH)D사분위치분층,분별계산당뇨병환병우세비OR치급95％치신구간.결과 소유년령단균존재불동정도적25-간유생소D결핍,조절년령、HOMA-IR、BMI후,혈청25-간유생소D수평여당뇨병발병정제량의뢰적부상관(r=-0.9271,P＜0.01),당혈청25-간유생소D수평체도94.6nmol/L이상시,당뇨병발병현저강저[OR =0.52,95％CI(0.23～0.78),P＜0.01].결론혈청25-간유생소D수평여2형당뇨병발병정명현부상관,혈청25-간유생소D수평강저증가당뇨병발병풍험.
Objectives To study the relationship between serum vitamin D and type 2 diabetes.Methods By randomly stratified sampling,589 volunteers were enrolled into this study.The volunteers were classified into diabetic and non-diabetic group according to the results of fasting plasma glucose or oral glucose tolerance test.The serum 25-hydroxyvitamin D levels were detected in 249 samples.The binary logistic regression analysis was used to analyze the relationship between diabetes and its related factors.The 25-hydroxyvitamin D levels in different age stage were analyzed by Cox-Staurt trend test.The odds ratios and 95％ confidence interval of diabetes were calculated respectively according to quartiles of serum 25-hydroxyvitamin D.Results The 25-hydroxyvitamin D levels were insufficient in some extent in all age sections of volunteers.Adjusting for age,HOMA-IR,BMI,odds ratios for diabetes varied inversely across quartiles of 25-hydroxyvitamin D in a dose-dependent pattern ( r =-0.9271,P ＜0.01 ).When serum 25-hydroxyvitamin D levels were above 94.6 nmol/L,the odds ratio of diabetes was significantly reduced [OR=0.52,95％ CI (0.23 ～0.78),P ＜0.01 ].Conclusions The serum 25-hydroxyvitamin D level was negative related with type 2 diabetes.The decreased serum levels 25-hydroxyvitamin D increased onset risk of diabetes.