CAJ | 학술논문

目的探讨血脂康胶囊对慢性心力衰竭患者的心功能及C反应蛋白(CRP)的影响.方法 48例冠心病慢性心力衰竭患者按就诊顺序随机分为2组,对照组(22例)应用血管紧张素转换酶抑制剂,β-受体阻滞剂、利尿剂和洋地黄制剂治疗,血脂康组(26例)在对照组基础上加用血脂康0.6 g,治疗半年,治疗前后采用超声心动图测定心功能,酶联免疫分析法测定CRP水平.结果血脂康组总有效率88.5%,优于对照组68.2%(P<0.05).血脂康组CBP在治疗后为(2.87±1.34)mg/L,较治疗前[(4.34±1.13)mg/L]显著降低(P<0.05),且显著低于对照组(P<0.05).治疗后2组心脏功能均得到明显改善,且血脂康组改善较对照组明显.结论血脂康在改善心功能的同时能降低血清CRP水平.
목적 탐토혈지강효낭대만성심력쇠갈환자적심공능급C반응단백(CRP)적영향.방법 48례관심병만성심력쇠갈환자안취진순서수궤분위2조,대조조(22례)응용혈관긴장소전환매억제제,β-수체조체제、이뇨제화양지황제제치료,혈지강조(26례)재대조조기출상가용혈지강0.6 g,치료반년,치료전후채용초성심동도측정심공능,매련면역분석법측정CRP수평.결과 혈지강조총유효솔88.5%,우우대조조68.2%(P<0.05).혈지강조CBP재치료후위(2.87±1.34)mg/L,교치료전[(4.34±1.13)mg/L]현저강저(P<0.05),차현저저우대조조(P<0.05).치료후2조심장공능균득도명현개선,차혈지강조개선교대조조명현.결론 혈지강재개선심공능적동시능강저혈청CRP수평.
Objective To investigate the effect of Xuezhikang capsule on chronic heart failure (CHF) and C-reactive protein (CRP). Methods Forty-eight patients were randomly divided into two groups. Control group (22 cases) had angiotensin-converting enzyme inhibitor β-blockers, diuretics and digitalis preparations treatment. Based on the same treatment of the control group, patients in Xuezhikang group (26 cases) were given extra Xuezhi-kang capsule 0.6g, twice a day. Echocardiography was taken to the two groups, and CRP level was tested by en-zyme-linked immunoabserbent assay. Results After treatment, the total effective rate of Xuezhikang group (88. 5%) was higher than that of control group (68.2%). CRP in Xuezhikang group(2.87±1.34) mg/L was decreased after treatment (P < 0.05). After treatment, the heart function of both group were significantly improved, especially in Xuezhikang group. Conclusion Xuezhikang capsule improves the heart function and reduces serum CRP level in chronic heart failure patients.