CAJ | 학술논문

采用酶联免疫双抗体夹心法动态监测39例肾移植患者术后血浆肿瘤坏死因子(TNF)的浓度,发现TNF水平存发毕感染和急性排斥时显著增高,较临床症状的出现早1～2天,术后平稳患者及急性肾功能衰竭患者无明显变化,排斥者在应用甲基强的松龙冲击有效时TNF下降,存应用抗胸腺细胞球蛋白和单克隆抗体治疗的排斥患者中,首次用药后TNF上升,随后下降,未降者排斥不能逆转.结果说明动态监测血浆TNF能预示排斥及感染的发生,对治疗效果及预后的判断也有重要价值.
채용매련면역쌍항체협심법동태감측39례신이식환자술후혈장종류배사인자(TNF)적농도,발현TNF수평존발필감염화급성배척시현저증고,교림상증상적출현조1～2천,술후평은환자급급성신공능쇠갈환자무명현변화,배척자재응용갑기강적송룡충격유효시TNF하강,존응용항흉선세포구단백화단극륭항체치료적배척환자중,수차용약후TNF상승,수후하강,미강자배척불능역전.결과설명동태감측혈장TNF능예시배척급감염적발생,대치료효과급예후적판단야유중요개치.
Tumour necrosis factor(TNF)is a kind of cellular protine factor produced by activated T-lymphocyte and macrophage.Recently,it was found that plasma TNF level was close related with immunologic condition of the cadaveric renal allograft recipients.The sequential monitoring of TNF by ELISA technique in 39 cases was reported.It was found that plasma TNF levels significantly elevated in acute rejection episodes and in infection,and not changed significantly in acute renal failure and in stable condition.ATG and OKT3 obviously affected the TNF levels in the first dose reaction and the whole treatment process.It is suggested that the monitoring of TNF is very important to evaluate the effect of treatment and the prognosis.