中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2011年
8期
51-52,55
,共3页
序贯疗法%幽门螺杆菌%消化性溃疡
序貫療法%幽門螺桿菌%消化性潰瘍
서관요법%유문라간균%소화성궤양
Sequential therapy%Helicobacter pylori%Peptic ulcer
目的 观察由奥美拉唑、胶体次枸橼酸铋钾、阿莫西林克拉维酸钾、左氧氟沙星组成的10日改良序贯疗法治疗幽门螺杆菌(Hp)阳性消化性溃疡的临床疗效及安全性.方法 将经胃镜检查确诊为消化性溃疡且Hp阳性的患者117例随机分为两组,治疗组(59例)前5 d口服奥美拉唑20 mg,2次/d,阿莫西林克拉维酸钾457 mg,2次/d,饭前半小时服胶体次枸橼酸铋钾200 mg,2次/d,后5 d口服奥美拉唑20 mg,2次/d,左氧氟沙星200 mg,2次/d;对照组(58例)口服奥美拉唑20 mg,2次/d,阿莫西林克拉维酸钾457 mg,2次/d,饭后服用克拉霉素500 mg,2次/d,疗程10 d,疗程结束4周后行13C-尿素呼气试验检测.结果 治疗组13C-尿素呼气试验转阴率为94.9%,对照组转阴率为70.6%,两组Hp转阴率比较差异具有统计学意义(P<0.05).结论 改良序贯疗法治疗Hp阳性消化性溃疡具有较高的Hp根除率,安全性好.
目的 觀察由奧美拉唑、膠體次枸櫞痠鉍鉀、阿莫西林剋拉維痠鉀、左氧氟沙星組成的10日改良序貫療法治療幽門螺桿菌(Hp)暘性消化性潰瘍的臨床療效及安全性.方法 將經胃鏡檢查確診為消化性潰瘍且Hp暘性的患者117例隨機分為兩組,治療組(59例)前5 d口服奧美拉唑20 mg,2次/d,阿莫西林剋拉維痠鉀457 mg,2次/d,飯前半小時服膠體次枸櫞痠鉍鉀200 mg,2次/d,後5 d口服奧美拉唑20 mg,2次/d,左氧氟沙星200 mg,2次/d;對照組(58例)口服奧美拉唑20 mg,2次/d,阿莫西林剋拉維痠鉀457 mg,2次/d,飯後服用剋拉黴素500 mg,2次/d,療程10 d,療程結束4週後行13C-尿素呼氣試驗檢測.結果 治療組13C-尿素呼氣試驗轉陰率為94.9%,對照組轉陰率為70.6%,兩組Hp轉陰率比較差異具有統計學意義(P<0.05).結論 改良序貫療法治療Hp暘性消化性潰瘍具有較高的Hp根除率,安全性好.
목적 관찰유오미랍서、효체차구연산필갑、아막서림극랍유산갑、좌양불사성조성적10일개량서관요법치료유문라간균(Hp)양성소화성궤양적림상료효급안전성.방법 장경위경검사학진위소화성궤양차Hp양성적환자117례수궤분위량조,치료조(59례)전5 d구복오미랍서20 mg,2차/d,아막서림극랍유산갑457 mg,2차/d,반전반소시복효체차구연산필갑200 mg,2차/d,후5 d구복오미랍서20 mg,2차/d,좌양불사성200 mg,2차/d;대조조(58례)구복오미랍서20 mg,2차/d,아막서림극랍유산갑457 mg,2차/d,반후복용극랍매소500 mg,2차/d,료정10 d,료정결속4주후행13C-뇨소호기시험검측.결과 치료조13C-뇨소호기시험전음솔위94.9%,대조조전음솔위70.6%,량조Hp전음솔비교차이구유통계학의의(P<0.05).결론 개량서관요법치료Hp양성소화성궤양구유교고적Hp근제솔,안전성호.
Objective To observe the clinical efficacy and safety of ten-days sequential therapy consisted of omeprazole,colloidal bismuth subcitrate potassium,amoxicillin and clavulanate potassium,levofloxacin on Helicobacter pylori (Hp)-positive peptic ulcer.Methods Totally 117 Helicobacter pylori-infected patients with peptic ulcer diagnosed by gastroscopy were enrolled.The patients were randomized divided into treatment group (59 cases) who received omeprazole 20 mg,2 times one day,amoxicillin and clavulanate potassium 457 mg,2 times one day,after meal colloidal bismuth subcitrate potassium 200 mg,2 times one day,for the first five days,and followed by omeprazole 20 mg,2 times one day,levofloxacin 200 mg,2 times one day,for the last five days;the control group (58 cases) treated with omeprazole 20 mg,2 times one day,amoxicillin and clavulanate potassium 457 mg,2 times one day,after meals clarithromycin 500 mg,2 times one day,for ten days,4 weeks underwent 13C-urea breath test.Results The treatment group 13C urea breath test negative rate was 94.9%,negative control group was 70.6%,compared two groups of Hp negative rate was significant difference (P＜0.05).Conclusions The modified sequential therapy of Hp-positive peptic ulcer with high eradication rates and safe is good.
