CAJ | 학술논문

　　目的探讨胃蛋白酶在成人分泌性中耳炎发病中的作用。方法选择2011年2月至2012年2月，我科住院有胃咽反流病史的15例成人分泌性中耳炎患者的中耳积液设为实验组，同期无胃咽反流病史的中耳炎15例，设为对照组。检测两组中耳渗液的胃蛋白酶水平，分析实验组患者年龄对中耳胃蛋白酶浓度的影响，以及胃蛋白酶浓度对患者病情的影响，对比两组的Gerd症状差异。结果实验组中9例患者的中耳渗液中含有胃蛋白酶，平均浓度为（198.2±335.9） ng/ml，中耳积液PH值为6.2～7.4；对照组15例中耳渗液中没有检出胃蛋白酶。实验组胃蛋白酶的含量在各年龄上没有明显的差异。两组的Gerd症状差异明显。结论胃蛋白酶可能是成人分泌性中耳炎发病因素之一，年龄对成人分泌性中耳炎患者中耳胃蛋白酶浓度无影响，胃蛋白酶浓度对患者病情有影响。
　　목적탐토위단백매재성인분비성중이염발병중적작용。방법선택2011년2월지2012년2월，아과주원유위인반류병사적15례성인분비성중이염환자적중이적액설위실험조，동기무위인반류병사적중이염15례，설위대조조。검측량조중이삼액적위단백매수평，분석실험조환자년령대중이위단백매농도적영향，이급위단백매농도대환자병정적영향，대비량조적Gerd증상차이。결과실험조중9례환자적중이삼액중함유위단백매，평균농도위（198.2±335.9） ng/ml，중이적액PH치위6.2～7.4；대조조15례중이삼액중몰유검출위단백매。실험조위단백매적함량재각년령상몰유명현적차이。량조적Gerd증상차이명현。결론위단백매가능시성인분비성중이염발병인소지일，년령대성인분비성중이염환자중이위단백매농도무영향，위단백매농도대환자병정유영향。
Objective to investigate the pepsin secretory otitis media in the role of adult. Method select 2011 february to 2012 february, 15 cases of hospitalized adult patients with secretory otitis media, for the observation group, the same period without otitis media and 15 cases of adult volunteers, as a control group. to observe the liquid penetration properties with pepsin in the ear. statistical comparison, P<0.05, there was statistical significance. Results The observation group of 9 cases of middle ear exudate containing pepsin, the average concentration of (198.2 ± 335.9) ng/ml, middle ear effusion pH was 6.2-7.4, comparison group;15 volunteers was not detected in the middle ear of pepsin. There were no significant differences in the contents of pepsin in each age;the questionnaire results showed symptoms of Gerd difference between the two groups was not obvious. conclusion Pepsin is an important factor in adult secretory otitis media. Middle age on adults with secretory otitis media patients had no effect on concentration of pepsin, pepsin concentration have effects on patients.