当代医药论丛
噹代醫藥論叢
당대의약론총
Contemporary Medicine Forum
2014年
4期
42-44
,共3页
邢沙沙%郭玉%唐国涛%胡杰
邢沙沙%郭玉%唐國濤%鬍傑
형사사%곽옥%당국도%호걸
Seroquel XR%富马酸喹硫平%体外释放%累计释放度
Seroquel XR%富馬痠喹硫平%體外釋放%纍計釋放度
Seroquel XR%부마산규류평%체외석방%루계석방도
Seroquel XR,Quetiapine fumarate%Release in vitro,Accumulative release rate
目的：研究Seroquel XR在不同释放介质的释放情况。方法：采用USP32 I法（篮法），以不同PH值的释放介质，用紫外分光光度计在288nm下测定喹硫平含量，之后计算累计释放度并绘制释放曲线。结果：Seroquel XR在不同释放介质的累计释放度不同。片剂的重现性良好。结论：本次试验为Seroquel XR研究者提供了4条Seroquel XR释放曲线。
目的：研究Seroquel XR在不同釋放介質的釋放情況。方法：採用USP32 I法（籃法），以不同PH值的釋放介質，用紫外分光光度計在288nm下測定喹硫平含量，之後計算纍計釋放度併繪製釋放麯線。結果：Seroquel XR在不同釋放介質的纍計釋放度不同。片劑的重現性良好。結論：本次試驗為Seroquel XR研究者提供瞭4條Seroquel XR釋放麯線。
목적：연구Seroquel XR재불동석방개질적석방정황。방법：채용USP32 I법（람법），이불동PH치적석방개질，용자외분광광도계재288nm하측정규류평함량，지후계산루계석방도병회제석방곡선。결과：Seroquel XR재불동석방개질적루계석방도불동。편제적중현성량호。결론：본차시험위Seroquel XR연구자제공료4조Seroquel XR석방곡선。
OBJECTIVE: To research drug release of Seroquel XR in different release mediums in vitro. METHODS: The release models in vitro were USP I (Basket), 100r/min in different release mediums. The content of Quetiapine Fumarate was determined by ultraviolet-visible spectrophotomery at 288nm and accumulative release rates were calculated , then drawing the curve of release rate. RESULTS: The accumulative release rate of Seroquel XR were different in different release mediums. The tablets were reproducible. CONCLUSION: The important data of the four curves were provided to researchers.
