CAJ | 학술논문

　　目的：归纳异钩藤碱药动学及其含量测定方法的研究进展。方法：查阅国内外有关文献进行综合分析。结果：异钩藤碱是中药钩藤中的主要生物碱之一，目前主要采用HPLC、反相HPLC等方法检测动物组织和血液中异钩藤碱浓度，并进行了异钩藤碱在大鼠、兔、猫体内的药动学研究；采用HPLC、超高效液相色谱、非水毛细管电泳、高效毛细管电泳、薄层色谱傅里叶变换表面增强拉曼散射法测定钩藤药材中异钩藤碱的含量。结论：虽然对异钩藤碱药动学及其含量检测方法研究取得了一定成果，随着科技发展和高端检测仪器的应用，还需采用更加快速、便捷、精确的检测方法，为异钩藤碱今后的进一步研究和开发提供技术支撑。
　　목적：귀납이구등감약동학급기함량측정방법적연구진전。방법：사열국내외유관문헌진행종합분석。결과：이구등감시중약구등중적주요생물감지일，목전주요채용HPLC、반상HPLC등방법검측동물조직화혈액중이구등감농도，병진행료이구등감재대서、토、묘체내적약동학연구；채용HPLC、초고효액상색보、비수모세관전영、고효모세관전영、박층색보부리협변환표면증강랍만산사법측정구등약재중이구등감적함량。결론：수연대이구등감약동학급기함량검측방법연구취득료일정성과，수착과기발전화고단검측의기적응용，환수채용경가쾌속、편첩、정학적검측방법，위이구등감금후적진일보연구화개발제공기술지탱。
Objective:Isorhynchophylline is one of the major alkaloids of Uncaria rhynchophylla. Methods:To search the related domestic and foreign literatures,and to analyze them comprehensively. Results:In animal tissues and blood,isorhynchophylline concentration is almost measured by high -performance liquid chromatography (HPLC)and reversed -phase HPLC; and its pharmacokinetics is conducted in rat,rabbit, and cat. Isorhynchophylline content in Uncaria rhynchophylla is mainly determined by the methods of HPLC,ultra performance liquid chromatography,non-aqueous capillary electrophoresis,high-performance capillary electrophoresis,and thin layer chromatography-surface enhanced Raman spectroscopy. Conclusions: This paper reviews the above mentioned progress of isorhynchophylline to provide a reference for further research development and utilization.