浙江临床医学
浙江臨床醫學
절강림상의학
ZHEJIANG CLINICAL MEDICAL JOURNAL
2013年
8期
1114-1116
,共3页
王加红%苏枫%陈忠%陆献成
王加紅%囌楓%陳忠%陸獻成
왕가홍%소풍%진충%륙헌성
核转录因子-kB1%基因多态性%冠心病%早发
覈轉錄因子-kB1%基因多態性%冠心病%早髮
핵전록인자-kB1%기인다태성%관심병%조발
Nuclearfactor-kB%Gene polymorphism%Corornary heart disease%Premature
目的探讨核转录因子家族中NF-Kb1基因-94ins/delATTG 的多态性与我国早发冠心病(早发CHD)的相关性。方法对早发冠心病(病例组)92例和非冠心病(对照组)94例患者,采用苯酚-氯仿法提取DNA,聚合酶链反应-限制性片段长度多态性方法(PCR-RFLP)分析NF-kappaB1基因多态性。结果两组病例del/del型纯合子,ins/ins型纯合子,del/ins型杂合子基因型频率及ins、del等位基因频率差异无统计学意义。结论 NF-kappaB1基因多态性与我国早发冠心病的易感性可能无关。
目的探討覈轉錄因子傢族中NF-Kb1基因-94ins/delATTG 的多態性與我國早髮冠心病(早髮CHD)的相關性。方法對早髮冠心病(病例組)92例和非冠心病(對照組)94例患者,採用苯酚-氯倣法提取DNA,聚閤酶鏈反應-限製性片段長度多態性方法(PCR-RFLP)分析NF-kappaB1基因多態性。結果兩組病例del/del型純閤子,ins/ins型純閤子,del/ins型雜閤子基因型頻率及ins、del等位基因頻率差異無統計學意義。結論 NF-kappaB1基因多態性與我國早髮冠心病的易感性可能無關。
목적탐토핵전록인자가족중NF-Kb1기인-94ins/delATTG 적다태성여아국조발관심병(조발CHD)적상관성。방법대조발관심병(병례조)92례화비관심병(대조조)94례환자,채용분분-록방법제취DNA,취합매련반응-한제성편단장도다태성방법(PCR-RFLP)분석NF-kappaB1기인다태성。결과량조병례del/del형순합자,ins/ins형순합자,del/ins형잡합자기인형빈솔급ins、del등위기인빈솔차이무통계학의의。결론 NF-kappaB1기인다태성여아국조발관심병적역감성가능무관。
Objective To investigate the relationship between Nuclearfactor-kB(NF-kB)gene polymorphisms and premature coronary heart disease. Methods Ninty two patients of premature coronary heart diease and 94 controls were enrolled and polymerase chain reaction-restriction fragement length polymorphism(PCR-RFLP)was used to analysis,NF-kB1 gene polymorphism .Results There were no significant difference of the genotype distribution and alleles of gene between patients with premature coronary heart disease and controls(P>0.05). Conclution The Results suggest that NF-kB1 gene polymorphisms are not associated with an increased risk of premature coronary heart disease in China.