CAJ | 학술논문

目的：探讨苯磺酸氨氯地平片对动态血压季节性变异的影响。方法96名轻中度原发性高血压患者随机分为3组，即非洛地平缓释片组（F组）、硝苯地平控释片（X组）和苯磺酸氨氯地平片（A组），每组32例患者，所有患者用安慰剂洗脱2周后分别给予非洛地平缓释片5mg/d、硝苯地平控释片30mg/d和苯磺酸氨氯地平片5mg/d治疗，1月后血压未达标加用贝那普利片10mg/d。所有患者均于冬季和夏季分别行24小时动态血压监测，观察血压晨峰（ MBPS）和冬夏两季血压达标率变化。结果无论24小时、日间还是夜间，冬季 A 组血压达标率（78.1％，78.1％，75.0％）均明显高于 F 组（62.5％，65.6％，56.3％）和X组（65.6％，68.8％，65.6％）（均P＜0.01）。冬季A组MBPS（33.7±9.7mmHg）显著低于F组（38.0±11.4mmHg，P＜0.01）和X组（36.9±10.9mmHg，P＜0.05）。结论与非洛地平缓释片和硝苯地平控释片比较，苯磺酸氨氯地平片降低血压季节性变异更明显，冬季24小时动态血压达标率更高。
목적：탐토분광산안록지평편대동태혈압계절성변이적영향。방법96명경중도원발성고혈압환자수궤분위3조，즉비락지평완석편조（F조）、초분지평공석편（X조）화분광산안록지평편（A조），매조32례환자，소유환자용안위제세탈2주후분별급여비락지평완석편5mg/d、초분지평공석편30mg/d화분광산안록지평편5mg/d치료，1월후혈압미체표가용패나보리편10mg/d。소유환자균우동계화하계분별행24소시동태혈압감측，관찰혈압신봉（ MBPS）화동하량계혈압체표솔변화。결과무론24소시、일간환시야간，동계 A 조혈압체표솔（78.1％，78.1％，75.0％）균명현고우 F 조（62.5％，65.6％，56.3％）화X조（65.6％，68.8％，65.6％）（균P＜0.01）。동계A조MBPS（33.7±9.7mmHg）현저저우F조（38.0±11.4mmHg，P＜0.01）화X조（36.9±10.9mmHg，P＜0.05）。결론여비락지평완석편화초분지평공석편비교，분광산안록지평편강저혈압계절성변이경명현，동계24소시동태혈압체표솔경고。
Objective To explore the antihypertensive effects of long-acting calcium antagonists on seasonal variability of ambu-latory blood pressure.Methods 96 patients with mild-to-moderate essential hypertension were randomly assigned to group F ,group X and group A,treated with felodipine extended-release tablet 5mg q.d,nifedipine controlled-release tablet 30mg q.d and amlodipine besylate tablet 5mg q.d,respectively.One month later,if the blood pressure was over the target ,benazepril tablet 10 mg q.d was added.All patients entered the study in the same autumn.24-h ambulatory blood-pressure monitoring were examined in autumn and summer.The change of the morning blood pressure surge ( MBPS) and the blood pressure control rates were observed.Results In winter,the control rates of 24 hours,daytime or nighttime blood pressure were higher in the group A (78.1%,78.1%,75.0%) than both the group F(62.5%,65.6%,56.3%) and the group X(65.6%,68.8%,65.6%) (all P<0.01).Moreover,MBPS of the group A(33.7 ±9.7 mmHg) was significantly lower than that of the group F (38.0 ±11.4 mmHg,P<0.01) and the group X(36.9 ±10.9 mmHg,P<0.05) in winter.Conclusion The amlodipine besylate can help more to lower blood pressure seasonal variabil -ity than the felodipine extended-release tablet and the nifedipine controlled-release tablet ,which lead to higher 24 hours blood pres-sure control rate in winter .