CAJ | 학술논문

目的：探讨替米沙坦对高血压合并糖调节受损患者的影响。方法：入选初诊为原发性高血压合并糖调节受损患者90例为研究对象，随机分为两组，观察组45例每天服用替米沙坦40～80mg，对照组45例每天服用厄贝沙坦75～150mg，共治疗12周。观察高血压患者治疗前后血压（BP）、空腹血糖（FPG）、餐后2h血糖（2hPG）、糖化血红蛋白（HbA1c）、空腹胰岛素（FINS）和胰岛素抵抗指数（IRI）水平的变化。结果：两组治疗后收缩压和舒张压均明显下降，与治疗前相比差异有统计学意义（P＜0.05）。两组BP治疗后比较差异无统计学意义（P＞0.05）。与对照组比较，观察组治疗后FPG、2hPG、HbA1c、FINS和IRI水平明显改善，两组比较差异有统计学意义（均P＜0.05）。结论：替米沙坦可改善高血压合并糖调节受损患者的糖代谢。
목적：탐토체미사탄대고혈압합병당조절수손환자적영향。방법：입선초진위원발성고혈압합병당조절수손환자90례위연구대상，수궤분위량조，관찰조45례매천복용체미사탄40～80mg，대조조45례매천복용액패사탄75～150mg，공치료12주。관찰고혈압환자치료전후혈압（BP）、공복혈당（FPG）、찬후2h혈당（2hPG）、당화혈홍단백（HbA1c）、공복이도소（FINS）화이도소저항지수（IRI）수평적변화。결과：량조치료후수축압화서장압균명현하강，여치료전상비차이유통계학의의（P＜0.05）。량조BP치료후비교차이무통계학의의（P＞0.05）。여대조조비교，관찰조치료후FPG、2hPG、HbA1c、FINS화IRI수평명현개선，량조비교차이유통계학의의（균P＜0.05）。결론：체미사탄가개선고혈압합병당조절수손환자적당대사。
Objective: To explore the inlfuence of telmisartan on the impaired glucose regulation (IGR) of patients with hypertention.Methods: Ninety patients with IGR and hypertension who were selected in our hospi-tal were randomly divided into two groups. The patients in study group (45 cases) were treated by taking telmis-artan 40~80 mg per day for 12 weeks and the patients in control group (45 cases) were required to take irbesartan 75~150 mg per day for 12 weeks. Their blood pressure (BP) and the insulin sensitivity including fasting plasma glucose (FPG), 2 hours postprandial glucose (2hPG), glycosylated hemoglobin, fasting insulin (FINS) and insulin resistance index (IRI) were observed and analysed after 12 weeks.Results: Systolic blood pressure (SBP) and diastolic blood pressure (DBP) decreased signiifcantly in both groups after treatment (P<0.05). Compared with the control group, FBG, 2hPG, HbA1c, FINS and IRI in the study group decreased after telmisartan treatment (P<0.05).Conclusion: Telmisartan can effectively improve glucose metabolism in the patients with IGR and hypertension.