CAJ | 학술논문

　　目的研究成年广泛性焦虑障碍患者胼胝体可能存在的微细结构异常，并探讨其可能的机制。方法选择成年广泛性焦虑障碍患者(病例组)及年龄与性别相匹配的同期健康体检者(对照组)各28例进行磁共振弥散张量成像检查；分别于胼胝体膝部、体部及压部最厚的部位设置感兴趣区，测取部分各向异性值(FA值)和表观弥散系数值(ADC值)。结果病例组患者胼胝体膝部及体部FA值均明显低于对照组(P <0.01)，而胼胝体压部FA值两组间无明显差异(P >0.05)；胼胝体各部位ADC值两组间无明显差异(P >0.05)。病例组患者年龄与胼胝体各部位FA值及ADC值均无统计学相关性(P >0.05)；病程与胼胝体膝部及体部FA值均呈统计学负相关(P <0.01)，而与胼胝体压部FA值及各部位ADC值均无统计学相关性(P >0.05)；HAM-A评分与胼胝体膝部及体部FA值均呈统计学负相关(P <0.01)，而与胼胝体压部FA值及各部位ADC值均无统计学相关性(P >0.05)。结论广泛性焦虑障碍患者存在胼胝体神经纤维微细结构完整性的损害。
　　목적연구성년엄범성초필장애환자변지체가능존재적미세결구이상，병탐토기가능적궤제。방법선택성년엄범성초필장애환자(병례조)급년령여성별상필배적동기건강체검자(대조조)각28례진행자공진미산장량성상검사；분별우변지체슬부、체부급압부최후적부위설치감흥취구，측취부분각향이성치(FA치)화표관미산계수치(ADC치)。결과병례조환자변지체슬부급체부FA치균명현저우대조조(P <0.01)，이변지체압부FA치량조간무명현차이(P >0.05)；변지체각부위ADC치량조간무명현차이(P >0.05)。병례조환자년령여변지체각부위FA치급ADC치균무통계학상관성(P >0.05)；병정여변지체슬부급체부FA치균정통계학부상관(P <0.01)，이여변지체압부FA치급각부위ADC치균무통계학상관성(P >0.05)；HAM-A평분여변지체슬부급체부FA치균정통계학부상관(P <0.01)，이여변지체압부FA치급각부위ADC치균무통계학상관성(P >0.05)。결론엄범성초필장애환자존재변지체신경섬유미세결구완정성적손해。
Objective The aim of this study was to investigate the possible microstructural abnormalities of the corpus callosum(CC) in adult patients with generalized anxiety disorder(GAD). Methods Diffusion tensor magnetic resonance imaging(DT-MRI) was carried out in 28 adult patients with GAD and 28 age- and sex- matched healthy controls. Fractional anisotropy(FA) and apparent diffusion coefficient(ADC) were measured at genu, body, and splenium of the CC, respectively. Results The FA values at the genu and body of the CC from patients with GAD were significantly lower than the control(P <0.01). However, the FA values at the splenium of the CC were not significant different between the two groups(P >0.05). The ADC values of the above regions were not significantly different between the two groups(P >0.05). There were negative correlations between disease course and the FA values at the genu and body of the CC(P <0.01). Negative correlations were also found between Hamilton anxiety scores and FA values at the genu and body of the CC(P <0.01). Conclusion There were integrity changes of neurofibrotic microstructures in the CC in adult patients with GAD, which can be detected by DT-MRI.