CAJ | 학술논문

目的：探讨米诺环素联合螺内酯治疗中度女性成人痤疮的疗效及安全性。方法：将2011年到2013年广州南沙中心医院和广州市第一人民医院皮肤科收治的148例中度女性成人痤疮患者随机分为：A组(50例),采用米诺环素联合螺内酯、阿达帕林凝胶治疗；B组(52例)采用米诺环素联合阿达帕林凝胶治疗；C组(46例)采用阿达帕林凝胶治疗。结果：治疗时间分4个阶段2、4、6、8周。其A组有效率分别为48％、62％、82％、94％,B组为28.85％、40.38％、63.46％、78.85％,C组为10.87％,17.39％、23.91％、28.26％,A、B、C组两两比较有效率差异均有统计学意义(均P<0.05)。结论：米诺环素联合螺内酯治疗中度女性成人痤疮安全有效。
목적：탐토미낙배소연합라내지치료중도녀성성인좌창적료효급안전성。방법：장2011년도2013년엄주남사중심의원화엄주시제일인민의원피부과수치적148례중도녀성성인좌창환자수궤분위：A조(50례),채용미낙배소연합라내지、아체파림응효치료；B조(52례)채용미낙배소연합아체파림응효치료；C조(46례)채용아체파림응효치료。결과：치료시간분4개계단2、4、6、8주。기A조유효솔분별위48％、62％、82％、94％,B조위28.85％、40.38％、63.46％、78.85％,C조위10.87％,17.39％、23.91％、28.26％,A、B、C조량량비교유효솔차이균유통계학의의(균P<0.05)。결론：미낙배소연합라내지치료중도녀성성인좌창안전유효。
Objective: To determine the efficacy and safety of minocycline and spironolactone in female adults with moderate acne. Methods: Between 2011 and 2013, we recruited 148 female adults with moderate acne from Guangzhou Nansha Central Hospital and Guangzhou First People’ s Hospital. Patients were randomly allocated to be treated with minocycline plus spironolactone and adapalene gel ( group A, n=50) , minocycline plus adapalene gel ( group B, n=52) and adapalene gel ( group C, n=46) . Results:After 2, 4, 6 and 8 weeks of treatment, group A yielded an effective rate of 48%, 62%, 82% and 94%, respectively. These figures were 28.85%, 40.38%, 63.46% and 78.85% in group B, and 10.87%, 17.39%, 23.91% and 28.26% in group C, respectively (all P<0.05). Conclusion: Minocycline plus spironolactone is effective and safe in female adults with moderate acne.