CAJ | 학술논문

　　目的探讨健康献血者不规则抗体筛查在临床输血中的意义。方法收集2011年8月至2012年10月3029名健康献血者的血液标本，采用盐水介质法和抗人球蛋白法进行不规则抗体筛查，抗体筛查阳性者做进一步鉴定，分析抗体特异性。结果对新疆维吾尔族自治区农三师图木舒克市中心血站3029例健康献血者进行不规则抗体筛查阳性17例（0．56％），其中抗-D阳性9例，抗-E阳性4例，抗-e阳性1例，抗-M阳性2例，抗A1阳性1例。男性不规则抗体阳性率为0．43％（6/1397），女性不规则抗体阳性率为0．67％（11/1632），差异无统计学意义（P＞0．05）。有输血史或妊娠史的健康献血者不规则抗体阳性率显著高于无输血史或妊娠史者（1．48％ vs 0．10％，P＜0．05）。结论常规对健康献血者血液标本进行不规则抗体筛查和鉴定，对保障临床用血安全、预防溶血性输血反应具有极其重要的意义。
　　목적탐토건강헌혈자불규칙항체사사재림상수혈중적의의。방법수집2011년8월지2012년10월3029명건강헌혈자적혈액표본，채용염수개질법화항인구단백법진행불규칙항체사사，항체사사양성자주진일보감정，분석항체특이성。결과대신강유오이족자치구농삼사도목서극시중심혈참3029례건강헌혈자진행불규칙항체사사양성17례（0．56％），기중항-D양성9례，항-E양성4례，항-e양성1례，항-M양성2례，항A1양성1례。남성불규칙항체양성솔위0．43％（6/1397），녀성불규칙항체양성솔위0．67％（11/1632），차이무통계학의의（P＞0．05）。유수혈사혹임신사적건강헌혈자불규칙항체양성솔현저고우무수혈사혹임신사자（1．48％ vs 0．10％，P＜0．05）。결론상규대건강헌혈자혈액표본진행불규칙항체사사화감정，대보장림상용혈안전、예방용혈성수혈반응구유겁기중요적의의。
Objective To investigate the significance of screening irregular antibodies among healthy blood do-nors for clinical blood transfusion .Methods 3 029 blood samples of healthy donors from Augst 2011 to October 2012 were collected .Saline medium method and Coombs test were used for irregular antibodies screening .The positive samples of the screening tests were further evaluated to analyze their antibody specificity .Results Among the 3 029 healthy donors ,17 cases (0 .56% ) were positive for irregular antibodies screening ,including 9 cases for anti-D anti-body ,4 cases for anti-E antibody ,1 case for anti-e antibody ,2 cases for anti-M antibody and 1 case for anti-A1 anti-body respectively .The positive rates of male and female were 0 .43% (6/1 397) and 0 .67% (11/1 632) .The differ-ence had no statistical significance (P>0 .05) .The positive rate of irregular antibody in healthy donors who had his-tory of blood transfusion or pregnancy was significantly higher than that in healthy donors without history of blood transfusion or pregnancy (1 .48 % vs 0 .1% ,P<0 .05) .Conclusion It might be with great significance to conduct routine screening and identification of irregular antibody among healthy donors ,which could ensures clinical transfu-sion safety and prevent hemolytic transfusion reaction .