中国卫生产业
中國衛生產業
중국위생산업
CHINA HEALTH INDUSTRY
2014年
16期
43-45
,共3页
中药%非酒精性脂肪性肝病%临床随机对照试验%系统评价
中藥%非酒精性脂肪性肝病%臨床隨機對照試驗%繫統評價
중약%비주정성지방성간병%림상수궤대조시험%계통평개
Traditional Chinese medicine%Nonalcoholic fatty liver disease%Clinical randomized controlled trials%Systematic review
目的：系统评价中药治疗非酒精性脂肪肝病的有效性和安全性，对重要药味的有效成分进行筛选。方法检索6个数据库中关于中药治疗非酒精性脂肪肝病的临床随机对照试验的文献，时限均为自1990年1月-2013年7月。由两位评价员独立地根据预定的纳入标准筛选合格的文献，提取资料并交叉核对。统一采用Jaded 质量记分法对纳入文献进行质量评价。采用Cochrane协作网提供的Revman5.2.0软件对纳入文献进行meta分析，用漏斗图进行发表性偏移的分析，从治疗方中遴选出使用频率较高的药味，分析中药降脂的有效活性成分。结果共纳入10篇文献，1395例患者，经质量评价其中4篇为高质量研究，其余6篇为低质量研究。Meta分析结果显示：中药治疗组总有效率优于西药或安慰剂治疗组，差异有统计学意义，P<0.01，RR=1.51(95%CI：1.41 to 1.62)。中药治疗非酒精性脂肪肝病的安全性较高。结论中药治疗非酒精性脂肪肝病疗效显著、安全性较好。
目的：繫統評價中藥治療非酒精性脂肪肝病的有效性和安全性，對重要藥味的有效成分進行篩選。方法檢索6箇數據庫中關于中藥治療非酒精性脂肪肝病的臨床隨機對照試驗的文獻，時限均為自1990年1月-2013年7月。由兩位評價員獨立地根據預定的納入標準篩選閤格的文獻，提取資料併交扠覈對。統一採用Jaded 質量記分法對納入文獻進行質量評價。採用Cochrane協作網提供的Revman5.2.0軟件對納入文獻進行meta分析，用漏鬥圖進行髮錶性偏移的分析，從治療方中遴選齣使用頻率較高的藥味，分析中藥降脂的有效活性成分。結果共納入10篇文獻，1395例患者，經質量評價其中4篇為高質量研究，其餘6篇為低質量研究。Meta分析結果顯示：中藥治療組總有效率優于西藥或安慰劑治療組，差異有統計學意義，P<0.01，RR=1.51(95%CI：1.41 to 1.62)。中藥治療非酒精性脂肪肝病的安全性較高。結論中藥治療非酒精性脂肪肝病療效顯著、安全性較好。
목적：계통평개중약치료비주정성지방간병적유효성화안전성，대중요약미적유효성분진행사선。방법검색6개수거고중관우중약치료비주정성지방간병적림상수궤대조시험적문헌，시한균위자1990년1월-2013년7월。유량위평개원독입지근거예정적납입표준사선합격적문헌，제취자료병교차핵대。통일채용Jaded 질량기분법대납입문헌진행질량평개。채용Cochrane협작망제공적Revman5.2.0연건대납입문헌진행meta분석，용루두도진행발표성편이적분석，종치료방중린선출사용빈솔교고적약미，분석중약강지적유효활성성분。결과공납입10편문헌，1395례환자，경질량평개기중4편위고질량연구，기여6편위저질량연구。Meta분석결과현시：중약치료조총유효솔우우서약혹안위제치료조，차이유통계학의의，P<0.01，RR=1.51(95%CI：1.41 to 1.62)。중약치료비주정성지방간병적안전성교고。결론중약치료비주정성지방간병료효현저、안전성교호。
Objective To systematic review the clinical effectiveness and safety of Traditional Chinese medicine (TCM) for nonal-coholic fatty liver disease (NAFLD) and to screen effective herbs and active components. Methods We searched the papers of clinical randomized controlled trials of treating NAFLD by TCM in six databases (from the date of January 1990 to July 2013).Ac-cording to the predetermined inclusion criteria, two estimators screening the papers, abstracted the information and checked across independently. Evaluating the literature quality by Jaded's score scale and judging the effectiveness by the software of Revman5.2.0 provided by the Cochrane network. The publication bias was studied by funnel plot analysis. Fifteen herbs used fre-quently were selected in the ten complex prescriptions, and their effective extracts were identified by bibliographic database. Re-sults There were ten literatures with 1395 cases included, of which 4 were of high quality and 6 of low quality. The results of Meta analyses showed: taking TCM could treat NAFLD more effectively than control groups in terms of the total effective rate and with-out serious adverse reactions. Conclusion The TCM on treatment of NAFLD has significant effects without serious side effects.
