CAJ | 학술논문

　　目的探讨老年人认知功能障碍与血浆同型半胱氨酸（Hcy）水平的关系。方法收集102例认知功能障碍老年患者为病例组，收集40例认知功能正常老年人为对照组；采用简易精神状态量表（MMSE）评分，将病例组分为轻度认知功能障碍（MCI）组52例和痴呆组50例，痴呆组其中老年性痴呆（AD）13例和血管性痴呆（VD）37例；各组均检测血浆 Hcy 水平，进行组间比较，血浆 Hcy 浓度与 MMSE 评分进行相关性分析。结果病例组血浆 Hcy 水平显著高于对照组（P ＜0.01），痴呆组血浆 Hcy 水平显著高于 MCI 组（P ＜0.01）；痴呆组血浆 Hcy 水平与 MMSE 评分呈明显负相关（P ＜0.01）。结论老年人认知功能障碍与高 Hcy 有关，而且认知障碍程度与血浆 Hcy 水平增高程度密切相关，高 Hcy 是老年人认知功能障碍的一个危险因素。
　　목적탐토노년인인지공능장애여혈장동형반광안산（Hcy）수평적관계。방법수집102례인지공능장애노년환자위병례조，수집40례인지공능정상노년인위대조조；채용간역정신상태량표（MMSE）평분，장병례조분위경도인지공능장애（MCI）조52례화치태조50례，치태조기중노년성치태（AD）13례화혈관성치태（VD）37례；각조균검측혈장 Hcy 수평，진행조간비교，혈장 Hcy 농도여 MMSE 평분진행상관성분석。결과병례조혈장 Hcy 수평현저고우대조조（P ＜0.01），치태조혈장 Hcy 수평현저고우 MCI 조（P ＜0.01）；치태조혈장 Hcy 수평여 MMSE 평분정명현부상관（P ＜0.01）。결론노년인인지공능장애여고 Hcy 유관，이차인지장애정도여혈장 Hcy 수평증고정도밀절상관，고 Hcy 시노년인인지공능장애적일개위험인소。
Objective To explore the correlation between cognitive impairment and plasma levels of homocysteine(Hcy) in elderly patients. Method 102 cases of elderly patients with cognitive impairment as study group and 40 normal elderly people as control group ; minimentalstateexam score was used to divide the control group into two group : mild cognitive dysfunction group with 52 cases and dementia group with 50 cases which included 13 cases of Alzheimer Disease and 37 cases of vascular dementia; plasma levels of homocysteine(Hcy) in every group were examined and compared between these groups,which were for correlation analysis with MMSE score. Results Plasma levels of homocysteine(Hcy) in study group was significantly higher than in control group(P<0.01) and plasma levels of homocysteine(Hcy) in dementia group was significantly higher than in MCI group(P<0.01); plasma levels of homocysteine(Hcy) in dementia group was negatively related with MMSE score. Conclusion Cognitive dysfunction of the elderly is correlated to high Hcy and the degree cognitive dysfunction is significantly correlated to the rise of plasma levels of homocysteine(Hcy). High homocysteine is the risk factor of cognitive dysfunction of elderly.