CAJ | 학술논문

改进盐酸氯卡色林消旋体的合成工艺，以对氯苯乙腈为起始原料，经还原得到中间体对氯苯乙胺，与2-氯丙酰氯反应，再经傅克烷基化反应成环，然后使用硼氢化钠、三氯化铝还原体系还原酰胺，最后成盐，得到目标产物，总收率达25.0%。
개진염산록잡색림소선체적합성공예，이대록분을정위기시원료，경환원득도중간체대록분을알，여2-록병선록반응，재경부극완기화반응성배，연후사용붕경화납、삼록화려환원체계환원선알，최후성염，득도목표산물，총수솔체25.0%。
This study is to synthesize lorcaserin hydrochloride racemate and improve the process. The 4-chlorophenethylamine was synthesized from 4-chlorobenzyl cyanide by reduction, and then it was reacted with 2-chloropropionyl chloride, through cyclization, reduction by sodium borohydride and aluminum chloride, finally through salt formation, to form lorcaserin hydrochloride racemate, with an overall yield of 25.0%.