CAJ | 학술논문

目的：比较放疗联合替莫唑胺与单纯放疗相比治疗成人恶性胶质瘤术后患者的疗效及安全性。方法检索CNKI、中国生物医学文献数据库、Pubmed、Medline、Cochrane Library、中国科技期刊数据库中的相关文献,纳入相关研究,2名研究员背对背独立提取有效数据,应用SPSS软件进行Meta分析。结果最终纳入8篇文献,包括418例患者。 Meta分析结果显示：在近期疗效方面,放疗联合替莫唑胺疗法高于单纯放疗疗法,差异有统计学意义(OR=3．42,95%CI：2．09~5．58,P<0．00001)；1年、2年、3年生存率放疗联合替莫唑胺疗法均高于单纯放疗疗法,差异均有统计学意义(1年生存率：OR=2．99,95%CI：1．85~4．84,P<0．00001；2年生存率：OR=4．52,95%CI：2．55~8．01,P<0．00001；3年生存率：OR=4．41,95%CI：1．83~10．64,P=0．0010),在安全性方面,放疗联合替莫唑胺疗法不增加恶心呕吐、骨髓抑制、头晕头痛不良反应发生,P>0．05。结论恶性胶质瘤术后患者行放疗同时联合替莫唑胺口服化疗明显增加临床疗效,安全可靠,值得临床推广。
목적：비교방료연합체막서알여단순방료상비치료성인악성효질류술후환자적료효급안전성。방법검색CNKI、중국생물의학문헌수거고、Pubmed、Medline、Cochrane Library、중국과기기간수거고중적상관문헌,납입상관연구,2명연구원배대배독립제취유효수거,응용SPSS연건진행Meta분석。결과최종납입8편문헌,포괄418례환자。 Meta분석결과현시：재근기료효방면,방료연합체막서알요법고우단순방료요법,차이유통계학의의(OR=3．42,95%CI：2．09~5．58,P<0．00001)；1년、2년、3년생존솔방료연합체막서알요법균고우단순방료요법,차이균유통계학의의(1년생존솔：OR=2．99,95%CI：1．85~4．84,P<0．00001；2년생존솔：OR=4．52,95%CI：2．55~8．01,P<0．00001；3년생존솔：OR=4．41,95%CI：1．83~10．64,P=0．0010),재안전성방면,방료연합체막서알요법불증가악심구토、골수억제、두훈두통불량반응발생,P>0．05。결론악성효질류술후환자행방료동시연합체막서알구복화료명현증가림상료효,안전가고,치득림상추엄。
Objective To compare the clinical effects and safety of brain malignant glioma treated with post-operative radiotherapy combined with Temozolomide chemotherapy and with radiotherapy only. Methods By search-ing CNKI,CBM,Pubmed、Medline,the studies were included if they were in accordance with inclusion criteria. Data were extracted and evaluated by two reviewers independently and data were analyzed using RevMan 5. 0. Results 8 studies were included with a total of 418 patients. Meta-analysis results were as follows:The total effective rate of the test group received postoperative radiotherapy combined with temozolomide chemotherapy was higher than that in the control group received radiotherapy only,the difference was statistically significant (OR=3. 42,95%CI:2. 09~5. 58, P<0. 000 01);The one-year、two-year and three-year survival rate of study group were higher than those in the control group,the difference was statistically significant ( one-year survival rate:OR=2. 99,95% CI:1. 85 ~4. 84,P<0. 000 01;two-year survival rate:OR=4. 52,95%CI:2. 55~8. 01,P<0. 000 01;three-year survival rate:OR=4. 41,95%CI:1. 83~10. 64,P=0. 001 0);The main side-effects were nausea,vomiting,myelosuppression and headache. There were no significant diferences between the two groups,P>0. 05. Conclusion The clinical effects of brain malignant glioma treated with postoperative radiotherapy combined with temozolomide chemotherapy was higher than with radiotherapy only,and there were no significant adverse reactions. In that case,it is worthy to be popularized.