中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2014年
6期
85-87
,共3页
丹红注射液%冠心病不稳定性心绞痛%安全性%可行性
丹紅註射液%冠心病不穩定性心絞痛%安全性%可行性
단홍주사액%관심병불은정성심교통%안전성%가행성
Danhong injection%Coronary heart disease unstable angina%Safety%Feasibility
目的：观察丹红注射液治疗冠心病不稳定型心绞痛的临床效果。方法选取我院2012年1月～2013年12月间收治的冠心病不稳定型心绞痛患者100例，随机分为对照组和观察组，均给予常规治疗，在此基础上，对照组加用硝酸甘油注射液，观察组加用丹红注射液治疗，比较两组临床疗效及治疗前后血液流变学参数及内皮功能改善情况。结果观察组患者治疗总有效率明显高于对照组（P＜0.05），治疗后患者血浆黏度、纤维蛋白原、红细胞沉降率及红细胞压积等血液流变学参数改善程度均明显优于对照组（P＜0.05）， FMD、NO、ET-1水平改善程度明显优于对照组，差异均具有统计学意义（P＜0.05）。结论丹红注射液治疗冠心病不稳定型心绞痛疗效显著，可有效改善患者血液流变学及内皮功能，值的临床推广应用。
目的：觀察丹紅註射液治療冠心病不穩定型心絞痛的臨床效果。方法選取我院2012年1月～2013年12月間收治的冠心病不穩定型心絞痛患者100例，隨機分為對照組和觀察組，均給予常規治療，在此基礎上，對照組加用硝痠甘油註射液，觀察組加用丹紅註射液治療，比較兩組臨床療效及治療前後血液流變學參數及內皮功能改善情況。結果觀察組患者治療總有效率明顯高于對照組（P＜0.05），治療後患者血漿黏度、纖維蛋白原、紅細胞沉降率及紅細胞壓積等血液流變學參數改善程度均明顯優于對照組（P＜0.05）， FMD、NO、ET-1水平改善程度明顯優于對照組，差異均具有統計學意義（P＜0.05）。結論丹紅註射液治療冠心病不穩定型心絞痛療效顯著，可有效改善患者血液流變學及內皮功能，值的臨床推廣應用。
목적：관찰단홍주사액치료관심병불은정형심교통적림상효과。방법선취아원2012년1월～2013년12월간수치적관심병불은정형심교통환자100례，수궤분위대조조화관찰조，균급여상규치료，재차기출상，대조조가용초산감유주사액，관찰조가용단홍주사액치료，비교량조림상료효급치료전후혈액류변학삼수급내피공능개선정황。결과관찰조환자치료총유효솔명현고우대조조（P＜0.05），치료후환자혈장점도、섬유단백원、홍세포침강솔급홍세포압적등혈액류변학삼수개선정도균명현우우대조조（P＜0.05）， FMD、NO、ET-1수평개선정도명현우우대조조，차이균구유통계학의의（P＜0.05）。결론단홍주사액치료관심병불은정형심교통료효현저，가유효개선환자혈액류변학급내피공능，치적림상추엄응용。
Objective To observe the clinical effect of Danhong injection in the treatment of coronary heart disease unstable angina. Methods One hundred patients with coronary heart disease unstable angina admitted to our hospital from January 2012 to December 2013 were selected and randomly divided into the control group and the observation group. Both groups received conventional treatment,on the basis of which the control group was given additional nitroglycerin injection and the observation group was given Danhong injection. The clinical efficacy and pre-treatment and post-treatment hemorheological parameters and endothelial function improvement conditions of the two groups were compared. Results The observation group had significantly higher total effective rate than the control group(P < 0.05). After treatment,the observation group had significantly better improvement degrees in plasma viscosity,fibrinogen,erythrocyte sedimentation rate,hematocrit and other hemorheological parameters than the control group(P < 0.05) and significantly better improvement degree in FMD,NO and ET-1 levels than the control group,with statistically significant differences(P < 0.05). Conclusion Danhong injection shows significant efficacy in the treatment of coronary heart disease unstable angina and can effectively improve the patients' hemorheological parameters and endothelial function,thereby worthy of clinical promotion and application.
