CAJ | 학술논문

目的：探讨神经节苷脂(GM-1)治疗新生儿缺氧缺血性脑病(HIE)的疗效及其及对神经元特异性烯醇化酶(serum neuron-specific enolase， NSE)水平的影响。方法：将60例新生儿缺氧缺血性脑病患儿随机分为GM1治疗组30例和常规治疗组30例。两组分别在生后24 h内及药物治疗7天后抽血检测血清神经元特异性烯醇化酶浓度，并在生后1～3天、4～6天、7～10天进行NBNA评分。结果：GM1治疗组其临床症状和体征改善明显优于常规治疗组(P<0.01)。GM1治疗组生后4～6天、7～10天NBNA评分明显高于常规治疗组(P<0.01)。GM1治疗组其血清神经元特异性烯醇化酶较常规治疗组明显下降(P<0.01)。结论：GM1在HIE患儿早期应用可稳定神经元细胞膜，减少细胞凋亡，从而减少NSE的释放，发挥神经保护作用。
목적：탐토신경절감지(GM-1)치료신생인결양결혈성뇌병(HIE)적료효급기급대신경원특이성희순화매(serum neuron-specific enolase， NSE)수평적영향。방법：장60례신생인결양결혈성뇌병환인수궤분위GM1치료조30례화상규치료조30례。량조분별재생후24 h내급약물치료7천후추혈검측혈청신경원특이성희순화매농도，병재생후1～3천、4～6천、7～10천진행NBNA평분。결과：GM1치료조기림상증상화체정개선명현우우상규치료조(P<0.01)。GM1치료조생후4～6천、7～10천NBNA평분명현고우상규치료조(P<0.01)。GM1치료조기혈청신경원특이성희순화매교상규치료조명현하강(P<0.01)。결론：GM1재HIE환인조기응용가은정신경원세포막，감소세포조망，종이감소NSE적석방，발휘신경보호작용。
Objective: To study the effect of ganglioside (GM1) on Serum neuron-specific enolase(NSE) in infants with neonatal hypoxic-ischemic encephalopathy(HIE). Methods:60 neonatal with HIE were divided into GM-1 treated group (n=30) and routine treatment group (n=30). The levels of NSE was separately detected in two groups after birth and on seventh day after treatment. The NBNA score were measured in two groups after 1~3 days,4~6 days and 7~10 days. Results: Ameliorated extent of clinical symptoms and physical signs between GM1 treatment group and routine treatment group had significant difference(P<0.01). The NBNA grades after 4~6 days and 7~10 days in GM1 treatment group were higher than those in routine treatment group (P<0.01). The level of NSE in GM1 treatment group was lower than that in routine treatment group(P<0.01). Conclusion: GM1 can reduce the NSE, promote the cure of neonatal hypoic-ischeic encephalopathy and play an neuron protective role in the disease.