CAJ | 학술논문

　　采用饱和水溶液法制备荆芥挥发油-β-环糊精（β-CD）包合物，利用差热-热重分析（DSC-TG）、傅里叶变换红外光谱（FT-IR）和扫描电镜（SEM）对包合物进行表征。通过正交试验优化最适宜包合工艺条件，根据相溶解度θθ法测定包合比、表观稳定常数以及包合反应的ΔG ，ΔH ，ΔS形式进行预测。结果表明：最适宜包合工艺条件为荆芥挥发油与β-CD的比例1∶8（mL∶g），乙醇与水的比例1∶3（mL∶mL），包合温度40℃，搅拌速度4500 r/min；β-CD包合荆芥挥发油的包合比1∶1；表观稳定常数随温度的升高而θθθ降低，β-CD包合荆芥挥发油反应的ΔG ，ΔH ，ΔS均为负值，说明β-CD包合荆芥挥发油反应是一个放热反应。此外，模拟的结果表明，β-CD包合胡薄荷酮的理想模型是胡薄荷酮的甲基端从β-CD的小口端进入β-CD内腔。θ，并用Chem3D软件对β-CD包合胡薄荷酮的包合
　　채용포화수용액법제비형개휘발유-β-배호정（β-CD）포합물，이용차열-열중분석（DSC-TG）、부리협변환홍외광보（FT-IR）화소묘전경（SEM）대포합물진행표정。통과정교시험우화최괄의포합공예조건，근거상용해도θθ법측정포합비、표관은정상수이급포합반응적ΔG ，ΔH ，ΔS형식진행예측。결과표명：최괄의포합공예조건위형개휘발유여β-CD적비례1∶8（mL∶g），을순여수적비례1∶3（mL∶mL），포합온도40℃，교반속도4500 r/min；β-CD포합형개휘발유적포합비1∶1；표관은정상수수온도적승고이θθθ강저，β-CD포합형개휘발유반응적ΔG ，ΔH ，ΔS균위부치，설명β-CD포합형개휘발유반응시일개방열반응。차외，모의적결과표명，β-CD포합호박하동적이상모형시호박하동적갑기단종β-CD적소구단진입β-CD내강。θ，병용Chem3D연건대β-CD포합호박하동적포합
Schizonepeta oil-β-Cyclodextrin(β-CD) inclusion compounds were prepared by saturated aqueous solution method, which were characterized by DSC-TG, SEM and FT-IR. Orthogonal experiment was performed for the most appropriate preparation process conditions. Inclusion ratio, apparent stability constant and three thermodynamic param-eters(ΔGθθθ, ΔH , ΔS ) of the inclusion reaction were determined by phase solubility method. Besides, the inclu-sion form was predicted by Chem3D. The results showed the most appropriate inclusion process conditions were as follows: the ratio of water to β-CD was 1∶8 (mL∶g), the ratio of ethanol to water was 1∶3 (mL∶mL), the inclusion temperature was 40℃and the speed of stirring was 4 500 r/min. The inclusion ratio was 1∶1, and the apparent stabili-ty constant decreased with temperature increased. At the same time,ΔGθθθ, ΔH , ΔS were all negative, which illustrat-ed the process was exothermic. In addition, the ideal inclusion form betweenβ-CD and Pulegone is the methyl end of Pulegone entering the intracavity.