CAJ | 학술논문

　　目的研究噪声习服后暴露和直接暴露于风洞噪声条件下豚鼠听力损失的易感性，和其耳蜗超微结构的变化。方法健康成年豚鼠100只随机分为习服后暴露组和直接暴露组，暴露于习服噪声和风洞噪声，于实验前、习服后、暴露后分别测定听性脑干反应阈值。根据其变化筛选噪声性听力损失易感和非易感个体，并通过扫描电镜观察其耳蜗形态学变化。结果习服后暴露组高强度风洞噪声引起的听阈升高程度较直接暴露组轻，其耳蜗内、外毛细胞病变较直接暴露组轻，各组内易感个体毛细胞损伤较非易感个体明显严重。结论噪声习服可有效减少风洞噪声暴露引起的听力损失和毛细胞损伤，但暴露于相同噪声条件下，其听力损失和毛细胞损伤存在较大个体差异。
　　목적연구조성습복후폭로화직접폭로우풍동조성조건하돈서은력손실적역감성，화기이와초미결구적변화。방법건강성년돈서100지수궤분위습복후폭로조화직접폭로조，폭로우습복조성화풍동조성，우실험전、습복후、폭로후분별측정은성뇌간반응역치。근거기변화사선조성성은력손실역감화비역감개체，병통과소묘전경관찰기이와형태학변화。결과습복후폭로조고강도풍동조성인기적은역승고정도교직접폭로조경，기이와내、외모세포병변교직접폭로조경，각조내역감개체모세포손상교비역감개체명현엄중。결론조성습복가유효감소풍동조성폭로인기적은력손실화모세포손상，단폭로우상동조성조건하，기은력손실화모세포손상존재교대개체차이。
Objective To investigate the effects of sound conditioning on wind tunnel noise-induced hearing loss and related cochlear ultra structure changes. Method One hundred healthy guinea pigs were randomly selected to receive sound-conditioning before exposure to wind tunnel noise, or to be exposed to wind tunnel noise without sound conditioning. Thresholds of auditory brainstem response (ABR) were measured at baseline, after sound conditioning and following exposure to wind tunnel noise. Cochlear morphological changes were examined under a scanning electron microscope. Susceptible and non-susceptible individuals to wind tunnel noise-induced hearing loss were identified based upon post-exposure ABR threshold changes. Result Sound-conditioned animals showed less ABR threshold elevation in general following subsequent exposure to wind tunnel noise, compared with those without conditioning, with less severe inner and outer hair cell damage in the cochlea. Hair cell damage in“susceptible”individuals appeared heavier than that in“non-susceptible”individuals in both sound conditioned and non-conditioned animals. Conclusion Sound conditioning can effectively reduce hearing loss and hair cell damage induced by wind tunnel noise exposure, although there appear to be significant inter-individual differ-ences among susceptible and non-susceptible individuals under the same noise exposure condition.