CAJ | 학술논문

　　合成了6种1-取代-4，5-二（4-氯苯基）咪唑．以对氯苯乙酸和氯苯为原料，经Friedel-Crafts酰基化反应、二氧化锡氧化、与多聚甲醛和乙酸铵环合制备了中间体4，5-二（4-氯苯基）咪唑（5），5再经取代得到3个1-取代-4，5-二-（4-氯苯基）咪唑类化合物6a-c ．6a再分别与液体胺经亲核取代反应得到3个1-取代乙酰胺类-4，5-二-（4-氯苯基）咪唑类化合物7a-c ．目标化合物结构用核磁共振氢谱和红外光谱进行了表征．
　　합성료6충1-취대-4，5-이（4-록분기）미서．이대록분을산화록분위원료，경Friedel-Crafts선기화반응、이양화석양화、여다취갑철화을산안배합제비료중간체4，5-이（4-록분기）미서（5），5재경취대득도3개1-취대-4，5-이-（4-록분기）미서류화합물6a-c ．6a재분별여액체알경친핵취대반응득도3개1-취대을선알류-4，5-이-（4-록분기）미서류화합물7a-c ．목표화합물결구용핵자공진경보화홍외광보진행료표정．
Six novel 1-substituted-4 ,5-bis(4-chlorophenyl) imidazoles were synthesized .First-ly ,starting materials 2-(4-chlorophenyl)acetic acid and chlorobenzene were used to synthesize 4 ,5-bis(4-chlorophenyl)-1H-imidazole intermediate (5) by Friedel-Crafts acylation reaction , selenium dioxide oxidation ,and cyclization with paraformaldehyde and ammonium acetate .As-obtained intermediate 5 was then adopted to prepare three novel 1-substituted-4 ,5-bis(4-chloro-phenyl) imidazoles (6a-c) by substitution reaction with three halogenides .Then as-synthesized product 6a was adopted to synthesize three novel 1-substituted-4 ,5-bis (4-chlorophenyl ) imidazoles (7a-c) by reaction with three amines at 100 ℃ .The structure of various target prod-ucts was characterized by means of nuclear magnetic resonance spectroscopy and infrared spec-trometry .