中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2014年
5期
743-745,746
,共4页
人乳头瘤病毒%基因亚型%年龄分布%多重感染
人乳頭瘤病毒%基因亞型%年齡分佈%多重感染
인유두류병독%기인아형%년령분포%다중감염
human papilloma virus ( HPV)%gene subtype%age distribution%multiple infection
目的:调查陕西省咸阳地区女性生殖道人乳头瘤病毒( HPV)亚型分布、年龄特征和多重感染情况,为宫颈癌的筛查及防治提供理论依据。方法采用反向点杂交基因扩增法对2012年1月至2014年1月在陕西中医学院附属医院就诊的1295例女性进行HPV基因亚型检测,包括18种高危型和10种低危型,分析比较感染程度、感染型别、年龄分布及多重感染情况。结果 HPV感染率为48.11%(623/1295),检出19种型别,15种高危亚型和4种低危亚型;亚型感染阳性总数为744例,高危型感染率为43.40%(562/1295),低危型感染率为14.05%(182/1295);高危亚型排在前3位的分别是HPV16(25.40%)、HPV52(9.68%)、HPV18(6.32%),低危亚型感染率最高者HPV6(8.60%);26~35岁组、46~55岁组感染率较高,分别为59.69%(194/325)和59.04%(98/166),两组间比较无显著性差异(χ2=0.02,P>0.05),两组分别与16~25岁组、36~45岁组、≥56岁组比较均有显著性差异(χ2值分别为13.49、30.70、13.34,均P<0.01);高危亚型感染率以26~35岁组及46~55岁为高,分别为52.92%(172/325)和47.59%(79/166),两组间比较无显著性差异(χ2=1.81,P>0.05);在所有感染患妇女中以单一亚型感染为主,感染率为40.93%(530/1295),在阳性构成比中占85.07%(530/623);在多重感染中以二重感染为主,感染率为5.71%(74/1295),在阳性构成比中占11.88%(74/623)。结论该地区HPV感染率较高,以单一高危亚型HPV16感染为主,26~35岁组和46~55岁组是HPV感染及高危亚型感染的高发阶段,在多重感染中以二重感染为主,既符合亚洲及中国地区人群的分布规律,又有一定的区域差异。
目的:調查陝西省鹹暘地區女性生殖道人乳頭瘤病毒( HPV)亞型分佈、年齡特徵和多重感染情況,為宮頸癌的篩查及防治提供理論依據。方法採用反嚮點雜交基因擴增法對2012年1月至2014年1月在陝西中醫學院附屬醫院就診的1295例女性進行HPV基因亞型檢測,包括18種高危型和10種低危型,分析比較感染程度、感染型彆、年齡分佈及多重感染情況。結果 HPV感染率為48.11%(623/1295),檢齣19種型彆,15種高危亞型和4種低危亞型;亞型感染暘性總數為744例,高危型感染率為43.40%(562/1295),低危型感染率為14.05%(182/1295);高危亞型排在前3位的分彆是HPV16(25.40%)、HPV52(9.68%)、HPV18(6.32%),低危亞型感染率最高者HPV6(8.60%);26~35歲組、46~55歲組感染率較高,分彆為59.69%(194/325)和59.04%(98/166),兩組間比較無顯著性差異(χ2=0.02,P>0.05),兩組分彆與16~25歲組、36~45歲組、≥56歲組比較均有顯著性差異(χ2值分彆為13.49、30.70、13.34,均P<0.01);高危亞型感染率以26~35歲組及46~55歲為高,分彆為52.92%(172/325)和47.59%(79/166),兩組間比較無顯著性差異(χ2=1.81,P>0.05);在所有感染患婦女中以單一亞型感染為主,感染率為40.93%(530/1295),在暘性構成比中佔85.07%(530/623);在多重感染中以二重感染為主,感染率為5.71%(74/1295),在暘性構成比中佔11.88%(74/623)。結論該地區HPV感染率較高,以單一高危亞型HPV16感染為主,26~35歲組和46~55歲組是HPV感染及高危亞型感染的高髮階段,在多重感染中以二重感染為主,既符閤亞洲及中國地區人群的分佈規律,又有一定的區域差異。
목적:조사합서성함양지구녀성생식도인유두류병독( HPV)아형분포、년령특정화다중감염정황,위궁경암적사사급방치제공이론의거。방법채용반향점잡교기인확증법대2012년1월지2014년1월재협서중의학원부속의원취진적1295례녀성진행HPV기인아형검측,포괄18충고위형화10충저위형,분석비교감염정도、감염형별、년령분포급다중감염정황。결과 HPV감염솔위48.11%(623/1295),검출19충형별,15충고위아형화4충저위아형;아형감염양성총수위744례,고위형감염솔위43.40%(562/1295),저위형감염솔위14.05%(182/1295);고위아형배재전3위적분별시HPV16(25.40%)、HPV52(9.68%)、HPV18(6.32%),저위아형감염솔최고자HPV6(8.60%);26~35세조、46~55세조감염솔교고,분별위59.69%(194/325)화59.04%(98/166),량조간비교무현저성차이(χ2=0.02,P>0.05),량조분별여16~25세조、36~45세조、≥56세조비교균유현저성차이(χ2치분별위13.49、30.70、13.34,균P<0.01);고위아형감염솔이26~35세조급46~55세위고,분별위52.92%(172/325)화47.59%(79/166),량조간비교무현저성차이(χ2=1.81,P>0.05);재소유감염환부녀중이단일아형감염위주,감염솔위40.93%(530/1295),재양성구성비중점85.07%(530/623);재다중감염중이이중감염위주,감염솔위5.71%(74/1295),재양성구성비중점11.88%(74/623)。결론해지구HPV감염솔교고,이단일고위아형HPV16감염위주,26~35세조화46~55세조시HPV감염급고위아형감염적고발계단,재다중감염중이이중감염위주,기부합아주급중국지구인군적분포규률,우유일정적구역차이。
Objective To investigate the subtype distribution, age features and multiple infections of female genital human papilloma virus ( HPV) in Xianyang in order to provide theoretical basis for screening, prevention and treatment of cervical cancer.Methods For 1 295 female patients visiting Affiliated Hospital of Shaanxi University of Chinese Medicine from January 2012 to January 2014, reverse dot blotting ( RDB) gene amplification method was adopted to detect HPV gene subtypes, including 18 high-risk subtypes and 10 low-risk subtypes.The degree and type of infection, age distribution and multiple infections were compared.Results HPV infection rate was 48.11%(623/1 295).Totally 19 types were detected, including 15 high-risk subtypes and 4 low-risk subtypes.The total number of individual positive subtype was 744, in which high-risk infection rate was 43.40%(562/1 295) and low-risk infection rate was 14.05%(182/1 295).The top three high-risk subtypes were HPV16 (25.40%), HPV52 (9.68%) and HPV18 (6.32%), respectively.The low-risk subtype with highest infection rate was HPV6 (8.60%).The infection rates of the group aged 26-35 years and the group aged 46-55 years were 59.69%(194/325) and 59.04%(98/166), respectively, which was not significantly different (χ2 =0.02, P>0.05). But they were significantly different from those of the group aged 16-25 years, the group aged 36-45 years and the group aged≥56 years (χ2 value was 13.49, 30.70 and 13.34, respectively, all P<0.01).The infection rate of high-risk subtypes was high in group aged 26-35 years and 46-55 years, which was 52.92% (172/325) and 47.59% (79/166), respectively.There was no significant difference between two groups (χ2 =1.81,P>0.05).Single genetic subtype infection was dominant and the infection rate was 40.93% (530/1 295) in all of infected women.Single genetic subtype infection accounted for 85.07% (530/623) in positive proportion.In multiple infections, superinfection was primary and the infection rate was 5.71%(74/1 295), which accounted for 11.88%(74/623) in positive proportion.Conclusion HPV infection rate is comparatively high in this region, with the major type of single high-risk HPV16 genotype. The age stages of 26 -35 years and 46 -55 years are high occurrence stages of HPV and high-risk subtype infections.In multiple infections, superinfection is primary.The above findings are consistent with the distribution of population in Asia and China, while there are some regional differences.