CAJ | 학술논문

　　冠状病毒（Coronavirus）家族成员是许多家畜、宠物包括人类的重要病原，引起多种急性和慢性疾病。冠状病毒有一巨大的基因组RNA，全长27~32 kb，编码结构蛋白、非结构蛋白和一些辅助蛋白。冠状病毒非结构蛋白（nonstructural prtein, nsp）由病毒编码的多聚蛋白1a/1ab水解而来，共有15或16个。这些非结构蛋白参与调节病毒基因组RNA的复制和亚基因组RNA的转录，或作为转录/复制复合体参与基因组的复制转录，并参与感染宿主等过程，是冠状病毒重要的功能蛋白。随着冠状病毒引起的严重急性呼吸系统综合症(severe acute respiratory syndrome，SARS）在中国乃至全球的爆发，对冠状病毒尤其是其非结构蛋白的研究得到越来越多的重视。本文就冠状病毒非结构蛋白的研究进展做一综述。
　　관상병독（Coronavirus）가족성원시허다가축、총물포괄인류적중요병원，인기다충급성화만성질병。관상병독유일거대적기인조RNA，전장27~32 kb，편마결구단백、비결구단백화일사보조단백。관상병독비결구단백（nonstructural prtein, nsp）유병독편마적다취단백1a/1ab수해이래，공유15혹16개。저사비결구단백삼여조절병독기인조RNA적복제화아기인조RNA적전록，혹작위전록/복제복합체삼여기인조적복제전록，병삼여감염숙주등과정，시관상병독중요적공능단백。수착관상병독인기적엄중급성호흡계통종합증(severe acute respiratory syndrome，SARS）재중국내지전구적폭발，대관상병독우기시기비결구단백적연구득도월래월다적중시。본문취관상병독비결구단백적연구진전주일종술。
Coronaviruses are important pathogens and cause acute and chronic diseases in livestock animals, pets as well as human beings. All coronaviruses share a large RNA genome of 27-32 kb in length encoding structure proteins, nonstructural proteins (nsps) and some accessory proteins. There are a total of 15 or 16 nsps in coronaviruses, which are derived from genomic RNA-encoding polyprotein 1a/1ab by proteolytical cleavage with virus-encoded proteases. Nonstructural proteins are involved in the replication and transcription of genome RNA, formation of the replication/transcription complexes, or other processes of virus infection. Research on coronavirus nsps has received much attention since SARS outbreaks in 2002. This review briefly summarizes research advance on coronavirus nsps.