中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2014年
10期
22-23
,共2页
心肺复苏%脑损伤%自主循环恢复
心肺複囌%腦損傷%自主循環恢複
심폐복소%뇌손상%자주순배회복
cardiopulmonary resuscitation%cerebral indury%ROSC
目的：探讨心脏骤停后延迟心肺复苏对大鼠海马病理变化的影响。方法成年雄性SD大鼠54只，随机分为假手术组（S组）、即刻复苏组（A组），延迟复苏组（B组），每组按血管穿刺后（S组）或自主循环恢复（ROSC）后（A组、B组）0.5 h断头取海马。A组、B组采用窒息法致大鼠心脏骤停和心肺复苏模型。光学显微镜下观察海马病理变化。结果光镜下，S组海马神经元表现为细胞形态、分布正常，几乎无变性、坏死神经元；与S组比较，A组、B组海马神经元可见明显的细胞水肿、核固缩等病理改变，且B组比A组损伤更为严重。结论延迟心肺复苏不仅降低心脏骤停大鼠ROSC成功率，亦可加重海马组织病理损伤。
目的：探討心髒驟停後延遲心肺複囌對大鼠海馬病理變化的影響。方法成年雄性SD大鼠54隻，隨機分為假手術組（S組）、即刻複囌組（A組），延遲複囌組（B組），每組按血管穿刺後（S組）或自主循環恢複（ROSC）後（A組、B組）0.5 h斷頭取海馬。A組、B組採用窒息法緻大鼠心髒驟停和心肺複囌模型。光學顯微鏡下觀察海馬病理變化。結果光鏡下，S組海馬神經元錶現為細胞形態、分佈正常，幾乎無變性、壞死神經元；與S組比較，A組、B組海馬神經元可見明顯的細胞水腫、覈固縮等病理改變，且B組比A組損傷更為嚴重。結論延遲心肺複囌不僅降低心髒驟停大鼠ROSC成功率，亦可加重海馬組織病理損傷。
목적：탐토심장취정후연지심폐복소대대서해마병리변화적영향。방법성년웅성SD대서54지，수궤분위가수술조（S조）、즉각복소조（A조），연지복소조（B조），매조안혈관천자후（S조）혹자주순배회복（ROSC）후（A조、B조）0.5 h단두취해마。A조、B조채용질식법치대서심장취정화심폐복소모형。광학현미경하관찰해마병리변화。결과광경하，S조해마신경원표현위세포형태、분포정상，궤호무변성、배사신경원；여S조비교，A조、B조해마신경원가견명현적세포수종、핵고축등병리개변，차B조비A조손상경위엄중。결론연지심폐복소불부강저심장취정대서ROSC성공솔，역가가중해마조직병리손상。
Objective To observe the effects of delayed CPR on hippocampal pathological injuries in rats after cardiac arrest. Methods The 54 adult SD rats were randomly divided into 3 groups:sham-operation control group (S group), immediated CPR group (A group),delayed CPR group (B group).Each group was divided on 0.5h after endovascular puncture in S group or after ROSC in A,B group. Asphyxiation cardiac arrest and CPR model was used in A,B group.The pathological changes of hippocampus were observed under light microscope. Results There were serious pathological changes in delayed CPR group. Conclusion The delayed CPR not only reduced the ROSC rate,also aggravated hippocampal pathological damage in rats .
