西部中医药
西部中醫藥
서부중의약
GANSU JOURNAL OF TRADITIONAL CHINESE MEDICINE
2014年
5期
60-63
,共4页
肾小球肾炎,慢性%中西医结合%Meta-分析
腎小毬腎炎,慢性%中西醫結閤%Meta-分析
신소구신염,만성%중서의결합%Meta-분석
glomerular nephritis,chronic%integrative medicine%Meta analysis
目的：系统评价中西医结合治疗慢性肾小球肾炎的临床疗效。方法：计算机检索万方和中国知网中关于中西医结合治疗慢性肾小球肾炎随机对照试验(RCT)。检索时限由建库至2012年12月。提取的相关数据采用RevMan5.0处理。结果：共纳入17个RCT。中西医结合治疗较单纯西药治疗总体疗效好[OR=3.88,95%CI(2.83,5.34)]；治疗组血肌酐降低较对照组明显[MD=-13.88,95%CI(-20.51,-7.24)]，治疗组24h尿蛋白定量降低较对照组明显[MD=-0.43，95%CI(-0.60，-0.26)]。结论：采用中西医结合治疗慢性肾小球肾炎的方法，较单纯采用西医常规治疗方法可更好缓解病情、改善症状，降低24小时尿蛋白量和血肌酐、保护肾脏功能。但鉴于纳入研究少，样本量少，且质量不高，研究评价方法特异性较大，并且存在评价时间的不同，故仍需要开展大样本多中心、方法科学和规范的高质量RCT，以求进一步验证中西医结合对慢性肾炎治疗的临床疗效。
目的：繫統評價中西醫結閤治療慢性腎小毬腎炎的臨床療效。方法：計算機檢索萬方和中國知網中關于中西醫結閤治療慢性腎小毬腎炎隨機對照試驗(RCT)。檢索時限由建庫至2012年12月。提取的相關數據採用RevMan5.0處理。結果：共納入17箇RCT。中西醫結閤治療較單純西藥治療總體療效好[OR=3.88,95%CI(2.83,5.34)]；治療組血肌酐降低較對照組明顯[MD=-13.88,95%CI(-20.51,-7.24)]，治療組24h尿蛋白定量降低較對照組明顯[MD=-0.43，95%CI(-0.60，-0.26)]。結論：採用中西醫結閤治療慢性腎小毬腎炎的方法，較單純採用西醫常規治療方法可更好緩解病情、改善癥狀，降低24小時尿蛋白量和血肌酐、保護腎髒功能。但鑒于納入研究少，樣本量少，且質量不高，研究評價方法特異性較大，併且存在評價時間的不同，故仍需要開展大樣本多中心、方法科學和規範的高質量RCT，以求進一步驗證中西醫結閤對慢性腎炎治療的臨床療效。
목적：계통평개중서의결합치료만성신소구신염적림상료효。방법：계산궤검색만방화중국지망중관우중서의결합치료만성신소구신염수궤대조시험(RCT)。검색시한유건고지2012년12월。제취적상관수거채용RevMan5.0처리。결과：공납입17개RCT。중서의결합치료교단순서약치료총체료효호[OR=3.88,95%CI(2.83,5.34)]；치료조혈기항강저교대조조명현[MD=-13.88,95%CI(-20.51,-7.24)]，치료조24h뇨단백정량강저교대조조명현[MD=-0.43，95%CI(-0.60，-0.26)]。결론：채용중서의결합치료만성신소구신염적방법，교단순채용서의상규치료방법가경호완해병정、개선증상，강저24소시뇨단백량화혈기항、보호신장공능。단감우납입연구소，양본량소，차질량불고，연구평개방법특이성교대，병차존재평개시간적불동，고잉수요개전대양본다중심、방법과학화규범적고질량RCT，이구진일보험증중서의결합대만성신염치료적림상료효。
Objective: To assess curative effects of integrative medicine in treating chronic glomerular nephritis(CGN) systematically. Methods: The articles on randomized controlled trial (RCT) of treating CGN by integrative medicine were searched inWangFangand CNKI. Time limit: from creating the database to December, 2012. Extracted related data was dealt with RevMan5.0. Results: Altogether 17 pieces of RCTs were included. Total effects of integrative medicine group were superior to these of western medicine group[OR=3.88, 95%CI (2.83, 5.34)]; serum creatinine (Scr) in the treatment group was decreased notably than that of the control group [MD=-13.88, 95%CI (-20.51, -7.24)], quantitative urinary protein of the treatment group was lower than that of the control group remarkably [MD=-0.43, 95%CI(-0.60, -0.26)]. Conclusion: Treating CGN by integrative medicine could relieve the condition, improve the symptoms, decrease the amount of 24 hours urinary protein and Scr, and protect renal func-tion than the effects of western medicine. Normal high quality RCT with large-sample, multi-centered and scientific method needs to be launched, in order to testify clinical effects of integrative medicine in treating CGN, since the in-clude studies are fewer, the samples are less, the quality is not high, the specificity of individual assessment is large and the evaluation time is different.
