CAJ | 학술논문

　　芹菜素（apigenin，4，5，7-三羟基黄酮）是一种常见的黄酮类化合物，具有广泛的药理作用。芹菜素可通过多种机制、多条途径抑制生殖系统肿瘤细胞的生长、侵袭，能够诱导肿瘤细胞发生凋亡。同时也有雌激素样作用，对睾丸组织有一定的损伤作用，通过下丘脑-垂体-性腺轴影响内分泌系统调节。然而，芹菜素生物学活性研究大多处于体外实验和动物模型阶段，因此，对芹菜素的作用机制及其临床作用还需进一步深入研究。
　　근채소（apigenin，4，5，7-삼간기황동）시일충상견적황동류화합물，구유엄범적약리작용。근채소가통과다충궤제、다조도경억제생식계통종류세포적생장、침습，능구유도종류세포발생조망。동시야유자격소양작용，대고환조직유일정적손상작용，통과하구뇌-수체-성선축영향내분비계통조절。연이，근채소생물학활성연구대다처우체외실험화동물모형계단，인차，대근채소적작용궤제급기림상작용환수진일보심입연구。
Apigenin,a common flavonoid,has extensive pharmacological activities. Apigenin inhibits growth and invasion of tumor cells of urogenital system through a variety of mechanisms and multiple pathways. Apigenin can also induce apoptosis of tumor cells. Meanwile,apigenin has a harmful effect on testis because of its estrogenic activity. Apigenin regulates the endocrine system by the hypothalamus-pituitary-gonadal axis. However,studies on the biological activity of apigenin are mostly in vitro or at animal model stage,and many mechanisms are still unclear. Therefore,it is necessary to study further the pharmacological effects and mechanisms for the further development of apigenin and its clinical application.