CAJ | 학술논문

他汀类药物治疗已成为缺血性卒中预防的标准方法,而且正在成为急性缺血性卒中的治疗选择.他汀类药物独立于胆固醇之外的多效性作用是将其用于缺血性卒中治疗的主要依据,这些多效性作用可能具有神经保护作用,进而改善患者的神经功能转归.同时,鉴于有研究显示他汀类药物的治疗作用存在剂量依赖性,因此主张采用大剂量他汀治疗.但是,围绕是否应将大剂量他汀类药物应用于不同机制的缺血性卒中患者仍然存在争论.
타정류약물치료이성위결혈성졸중예방적표준방법,이차정재성위급성결혈성졸중적치료선택.타정류약물독립우담고순지외적다효성작용시장기용우결혈성졸중치료적주요의거,저사다효성작용가능구유신경보호작용,진이개선환자적신경공능전귀.동시,감우유연구현시타정류약물적치료작용존재제량의뢰성,인차주장채용대제량타정치료.단시,위요시부응장대제량타정류약물응용우불동궤제적결혈성졸중환자잉연존재쟁론.
Statin therapy has become a standard method for the prevention of ischemic stroke,and is becoming a treatment option for acute ischemic stroke.The pleiotropic effects of statins which are independent of cholesterol are the main basis of using them in the treatment of ischemic stroke.It is regarded that these pleiotropic effects may have neuroprotective effects,thus improving the neurological functional outcome of patients.At the same time,studies have shown that the therapeutic effect of statins has dose-dependent manner; therefore,we advocate using high-dose statin therapy.However,about whether high-dose statins should be used in patients with ischemic stroke of the different mechanisms remain controversial.