CAJ | 학술논문

　　目的：本研究检测表皮生长因子样域7（EGFL）在胃癌中的表达并探讨其临床意义。方法：收集45例新鲜胃癌，用免疫组化SP法检测EGFL7的表达，分析其表达与肿瘤分级及微血管密度（MVD）的相关性。结果：有淋巴结转移组EGFL7阳性率高于无淋巴结转移组，浸润浆膜层组阳性率高于未浸润浆膜层组。癌组织中EGFL7的表达与淋巴结转移及浸润深度呈正相关（P<0.05）。胃癌低分化组MVD高于高分化组和中分化组；浸润至浆膜层组MVD高于未至浆膜层组；有淋巴结转移组MVD高于无淋巴结转移组。癌组织中MVD与分化程度、浸润深度及有无淋巴结转移呈正相关(P<0.05)。 EGFL7表达阳性的肿瘤组织中MVD均值33.80±10.56，高于EGFL7阴性表达组26.00±7.21（P<0.05），采用Pearson 进行相关分析，发现MVD 值与EGFL7表达正相关（r=0.313,P<0.05）。结论：EGFL7是一个新的预测胃癌临床进展的标记物，并可能成为胃癌患者抗血管新生的治疗靶点。
　　목적：본연구검측표피생장인자양역7（EGFL）재위암중적표체병탐토기림상의의。방법：수집45례신선위암，용면역조화SP법검측EGFL7적표체，분석기표체여종류분급급미혈관밀도（MVD）적상관성。결과：유림파결전이조EGFL7양성솔고우무림파결전이조，침윤장막층조양성솔고우미침윤장막층조。암조직중EGFL7적표체여림파결전이급침윤심도정정상관（P<0.05）。위암저분화조MVD고우고분화조화중분화조；침윤지장막층조MVD고우미지장막층조；유림파결전이조MVD고우무림파결전이조。암조직중MVD여분화정도、침윤심도급유무림파결전이정정상관(P<0.05)。 EGFL7표체양성적종류조직중MVD균치33.80±10.56，고우EGFL7음성표체조26.00±7.21（P<0.05），채용Pearson 진행상관분석，발현MVD 치여EGFL7표체정상관（r=0.313,P<0.05）。결론：EGFL7시일개신적예측위암림상진전적표기물，병가능성위위암환자항혈관신생적치료파점。
Objective In the current study, we examined the expression of EGF-like domain 7 (EGFL7), an endothelial cell-derived secreted factor, in gastric carcinoma and explored its clinical significance. Methods The expression of EGFL7 protein and MVD in 45 cases gastric carcinoma were detected by immunohistochemical methods.We also analyzed the correlations between the expression levels of EGFL7 and various clinical parame-ters, including tumor grade, tumor proliferation marker FⅧ, and microvessel density (MVD).Result The expres-sion of EGFL7 in the team which has lymph node metastasis is higher than the team which hasn't ,in the serosal invasion team is higher than the team which doesn't have serosal invasion. The expression of EGFL7 in gastric carcinoma is related with lymph node metastasis and tumor invasion (P<0.05).The MVD of poorly differentiation team is higher than the well-differentiation team and differentiated team. The serosal invasion team's MVD is higher than the team which is not,the team's MVD which has lymph node metastasis is higher than the team which hasn't.The MVD is related with tumor differentiation, invasion and lymph node metastasis(P<0.05).MVD in the tumor which express EGFL7 is 33.80±10.56, that is higher than the MVD in the tumor which don't express (26.00±7.21)(P<0.05).Pearson analysis shows MVD and EGFL7 expression is positive correlation (r=0.313,P<0.05)Conclusion Our data suggest that EGFL7 expression is a novel predictive factor for the clinical progression of gastric carcinoma, and may constitute a therapeutic target for anti-angiogenesis therapy in patients with the dis-ease.