CAJ | 학술논문

　　目的探讨高迁移率族蛋白A1（HMGA1）在肝细胞癌（HCC）、肝内胆管细胞癌（IHC）中的表达差异和临床意义。方法采用免疫组化SABC法对60例HCC、42例胆管细胞癌及10例正常肝脏组织标本中HMGA1的表达情况进行检测，并分析其与临床病理特点之间的关系。结果HMG组A1在10例正常肝脏组织中无一例表达，在HCC组中表达率为3.3％（2/60），在IHC组中表达率为66.7％（28/42）。IHC组与HCC组中HMGA1表达差异有统计学意义（P =0.000）；IHC组HMGA1与p53的表达呈正相关（r =0.673，P＜0.05）；1年内死亡患者的HMGA1表达水平（80.0％）较1年内存活患者的（33.3％）高，差异有统计学意义（P <0.05）。结论HMGA1可作为鉴别肝细胞癌与肝内胆管细胞癌的一个潜在指标。HMGA1在肝内胆管细胞癌的生成中可能发挥了重要作用，HMGA1在肝内胆管细胞癌的高表达提示预后不良。
　　목적탐토고천이솔족단백A1（HMGA1）재간세포암（HCC）、간내담관세포암（IHC）중적표체차이화림상의의。방법채용면역조화SABC법대60례HCC、42례담관세포암급10례정상간장조직표본중HMGA1적표체정황진행검측，병분석기여림상병리특점지간적관계。결과HMG조A1재10례정상간장조직중무일례표체，재HCC조중표체솔위3.3％（2/60），재IHC조중표체솔위66.7％（28/42）。IHC조여HCC조중HMGA1표체차이유통계학의의（P =0.000）；IHC조HMGA1여p53적표체정정상관（r =0.673，P＜0.05）；1년내사망환자적HMGA1표체수평（80.0％）교1년내존활환자적（33.3％）고，차이유통계학의의（P <0.05）。결론HMGA1가작위감별간세포암여간내담관세포암적일개잠재지표。HMGA1재간내담관세포암적생성중가능발휘료중요작용，HMGA1재간내담관세포암적고표체제시예후불량。
Objective To investigate the expression of HMGA1 in hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma(IHC) and its significance. Methods Immunohistochemistry (SABC method) was applied to detect HMGA1 expression in 60 HCC, 42 IHC, and 10 normal hepatic tissues. The relationship between HMGA1 expresssion and clinicpathological features of HCC and IHC was determined. Results No significant nuclear immunoreactivity was found in normal hepatic tissues, while 3.3%(2/60) of HCC, 66.7%(28/42) of IHC showed positive immunoreactivity, and there was significant difference between HCC and IHC(P =0.000). The expression level of HMGA1 was strongly correlated with the expression level of p53 (r =0.673,P <0.05). The expression of HMGA1 in patients who died in one year (80.0%) was higher than that of patients lived(33.3%), and the difference was significant(P < 0.05). Conclusions HMGA1 protein level may serve as a potential diagnostic marker that differentiate HCC from IHC. HMGA1 may play an important role in the development of IHC. The high expression level of HMGA1 in IHC is strongly correlated with bad prognosis.