CAJ | 학술논문

　　布鲁氏菌是兼性胞内生长的细菌病原体，其致病机理和胞内存活、复制有关。脂多糖（lipopolysaccharide，LPS）是布鲁氏菌外膜的主要成分，由类脂 A、核心寡聚糖和 O 抗原三部分组成，分别由多种与 LPS 合成相关的酶催化合成。布鲁氏菌LPS 在感染中起重要作用，是一种重要的毒力因子。LPS 的完整性决定布氏杆菌表型，对光滑型布鲁氏菌 LPS 合成过程中所需酶的编码基因进行突变可导致产生结构不完整的粗糙型 LPS，使其毒力变弱，经常被用作减毒活菌苗候选株进行研究。本文针对布鲁氏菌 LPS 的结构、生物合成和突变株的研究进展进行简要综述。
　　포로씨균시겸성포내생장적세균병원체，기치병궤리화포내존활、복제유관。지다당（lipopolysaccharide，LPS）시포로씨균외막적주요성분，유류지 A、핵심과취당화 O 항원삼부분조성，분별유다충여 LPS 합성상관적매최화합성。포로씨균LPS 재감염중기중요작용，시일충중요적독력인자。LPS 적완정성결정포씨간균표형，대광활형포로씨균 LPS 합성과정중소수매적편마기인진행돌변가도치산생결구불완정적조조형 LPS，사기독력변약，경상피용작감독활균묘후선주진행연구。본문침대포로씨균 LPS 적결구、생물합성화돌변주적연구진전진행간요종술。
Brucella is a facultative intracellular bacterial pathogen, and its virulence depends on the survival and replication properties in host cells. Lipopolysaccharide (LPS) is the main component of Brucella outer membrane, which consists of lipid A, core oligosaccharide and O-antigen, and whose biosynthesis catalyzed by dozens of enzymes. Brucella LPS plays a crucial role in the infection process and is an important virulence factor. The integrity of LPS determines the phenotype of Brucella. Mutation of Brucella LPS O-antigen results in the phenotype change of smooth to rough and attenuated virulence of the bacteria. So LPS has been a target for attenuating strains for vaccine development. In this review, the structure, the biosynthesis, as well as the progress in rough phenotype mutation of Brucella LPS and the potential use for vaccine candidate were briefly summarized.