CAJ | 학술논문

　　目的研究急性非ST段抬高型心肌梗死患者在行经皮冠状动脉介入治疗（PCI）围术期应用大剂量阿托伐他汀对改善术中心肌灌注及对术后30d内不良心血管事件（MACE）的影响。方法81例急性非ST段抬高性心肌梗死患者随机分为观察组（n=41）和对照组（n=40）。观察组顿服阿托伐他汀80mg，之后服用阿托伐他汀40mg/d 1周，1周后改为20mg/d。对照组给予阿托伐他汀20mg/d。PCI术中观察TIMI血流分级，记录校正的TIMI计帧值（CTFC）。随访观察术后30d内MACE发生率。结果（1）术中TIMI血流等级两组间无统计学差异（P＞0.05）。（2）两组间CTFC差异有统计学意义（27.3±6.9、31.5±7.3，P＜0.05）。（3）两组间30d内发生MACE差异无统计学意义（P＞0.05）。结论 NSTEMI患者PCI围术期负荷量阿托伐他汀强化治疗可以改善患者PCI术中冠状动脉血流灌注，减少无复流的发生率。
　　목적연구급성비ST단태고형심기경사환자재행경피관상동맥개입치료（PCI）위술기응용대제량아탁벌타정대개선술중심기관주급대술후30d내불양심혈관사건（MACE）적영향。방법81례급성비ST단태고성심기경사환자수궤분위관찰조（n=41）화대조조（n=40）。관찰조돈복아탁벌타정80mg，지후복용아탁벌타정40mg/d 1주，1주후개위20mg/d。대조조급여아탁벌타정20mg/d。PCI술중관찰TIMI혈류분급，기록교정적TIMI계정치（CTFC）。수방관찰술후30d내MACE발생솔。결과（1）술중TIMI혈류등급량조간무통계학차이（P＞0.05）。（2）량조간CTFC차이유통계학의의（27.3±6.9、31.5±7.3，P＜0.05）。（3）량조간30d내발생MACE차이무통계학의의（P＞0.05）。결론 NSTEMI환자PCI위술기부하량아탁벌타정강화치료가이개선환자PCI술중관상동맥혈류관주，감소무복류적발생솔。
Objective To study the effects of perioperetive high- dose atorvastatin on myocardial perfusion during percutaneous coronary intervention (PCI) and recent prognosis in patients with non ST- segment elevation myocardial infarction (NSTEMI). Methods 81 patients with NSTEMI were randomized divided into experimental group (n=41) and control group (n=40).The experimental group was treated with atorvastatin 80mg once and 40mg per day for a week, then 20mg per day. The control group was treated with atorvastatin 20mg per day. TIMI blood flow grade and corrected TIMI frame count were documented during PCI. Main adverse cardiovascular events during fol ow- up of 30 days were analyzed. Results Corrected TIMI frame count was significantly lower in experimental group than in control group (P<0.05). TIMI blood flow grade and adverse cardiovascular events were not significantly different between two groups(P>0.05). Conclusion Perioperetive high- dose atorvastatin treatment can improve coronary flow during PCI in patients with NSTEMI.