CAJ | 학술논문

　　以N-Boc苏氨醛为起始原料，经Wittig、Meisenheimer重排和催化氢化系列反应，不对称合成了天然产物三尖杉酯碱的侧链酸，中间体及目标产物结构经核磁共振（1 H NMR、13 C NMR）、红外光谱和质谱表征。结果表明，所用合成方法具有产率高、反应条件温和、操作简单等优点；目标化合物的总收率达30％。
　　이N-Boc소안철위기시원료，경Wittig、Meisenheimer중배화최화경화계렬반응，불대칭합성료천연산물삼첨삼지감적측련산，중간체급목표산물결구경핵자공진（1 H NMR、13 C NMR）、홍외광보화질보표정。결과표명，소용합성방법구유산솔고、반응조건온화、조작간단등우점；목표화합물적총수솔체30％。
Asymmetric synthesis of harringtonine side-chain acid was accomplished by a se-quence of Wittig and Meisenheimer rearrangements plus catalytic hydrogenation reaction in the presence of N-Boc amino aldehyde as the starting material .The structure of the intermediates and as-synthesized target product was characterized by means of nuclear magnetic resonance spectrometry (1 H NMR and 13 C NMR) ,infrared spectrometry and mass spectrometry .Results indicate that the methods adopted have the advantages of high yield ,mild reaction condition , and simple operation ,and the overall yield of target compound is as much as 30% .