神经损伤与功能重建
神經損傷與功能重建
신경손상여공능중건
NEURAL INJURY AND FUNCTIONAL RECONSTRUCTION
2013年
4期
273-275
,共3页
CADASIL%影像%鉴别诊断
CADASIL%影像%鑒彆診斷
CADASIL%영상%감별진단
CADASIL%image%differential diagnosis
目的：分析CADASIL的临床及影像学表现。方法：回顾性分析我院基因检测诊断为CADASIL的患者11例，分析其临床及影像特点。结果：患者平均发病年龄为46岁，无血管疾病危险因素10例，MRI病变基本呈双侧对称分布，7例出现对称的颞极白质病变，8例白质病变累及外囊，6例出现胼胝体梗死，7例出现脑干梗死。结论：中青年发病，有阳性家族史，无脑血管疾病危险因素的脑缺血性卒中患者，结合典型影像特点，排除其它白质病变及血管病变，辅助基因检测及皮肤、周围血管活检结果可诊断CADASIL。
目的：分析CADASIL的臨床及影像學錶現。方法：迴顧性分析我院基因檢測診斷為CADASIL的患者11例，分析其臨床及影像特點。結果：患者平均髮病年齡為46歲，無血管疾病危險因素10例，MRI病變基本呈雙側對稱分佈，7例齣現對稱的顳極白質病變，8例白質病變纍及外囊，6例齣現胼胝體梗死，7例齣現腦榦梗死。結論：中青年髮病，有暘性傢族史，無腦血管疾病危險因素的腦缺血性卒中患者，結閤典型影像特點，排除其它白質病變及血管病變，輔助基因檢測及皮膚、週圍血管活檢結果可診斷CADASIL。
목적：분석CADASIL적림상급영상학표현。방법：회고성분석아원기인검측진단위CADASIL적환자11례，분석기림상급영상특점。결과：환자평균발병년령위46세，무혈관질병위험인소10례，MRI병변기본정쌍측대칭분포，7례출현대칭적섭겁백질병변，8례백질병변루급외낭，6례출현변지체경사，7례출현뇌간경사。결론：중청년발병，유양성가족사，무뇌혈관질병위험인소적뇌결혈성졸중환자，결합전형영상특점，배제기타백질병변급혈관병변，보조기인검측급피부、주위혈관활검결과가진단CADASIL。
Objective:To analyze the clinical and imaging manifestations of patients with CADASIL. Methods:the clinical and imaging data of 11 patients diagnosed by genetic test as CADASIL were retro-spectively analyzed. Results:The average age of onset is about 46 years old and 10 cases have no risk fac-tors for vascular diseases. Brain MRI showed that the lesions were bilateral symmetric distributions, in-cluding symmetrical temporal white matter lesions, infarcts in the external capsules callosum infarction, and brainstem infarction. Conclusion: Onset in young cerebral ischemia patients, with family members with the similar presentation, typical changes on brain MRI, no risk factors for cerebral vascular diseases may be suggestive of CADASIL. Genetic testing and skin or peripheral vascular biopsy will confirm the diagnosis. .
