神经损伤与功能重建
神經損傷與功能重建
신경손상여공능중건
NEURAL INJURY AND FUNCTIONAL RECONSTRUCTION
2013年
4期
257-259
,共3页
邢建丽%刘莹%张法军%王苏
邢建麗%劉瑩%張法軍%王囌
형건려%류형%장법군%왕소
2型糖尿病%急性脑梗死%血脂异常%动脉粥样硬化
2型糖尿病%急性腦梗死%血脂異常%動脈粥樣硬化
2형당뇨병%급성뇌경사%혈지이상%동맥죽양경화
type 2 diabetes%acute cerebral infarction%dyslipidemia%apolipoprotein
目的：对2型糖尿病急性脑梗死患者的血脂及相关临床特点进行分析。方法：回顾性收集急性脑梗死患者116例，根据是否伴2型糖尿病分为糖尿病组70例和非糖尿病组46例。采集血清总胆固醇(TCHOL)、甘油三酯(TG)、空腹血糖(GLU)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A(ApoA)、载脂蛋白B(ApoB)及头部MRI、颈动脉超声检查结果，进行统计学分析。结果：糖尿病组空腹GLU、TG、ApoB、TCHOL血清浓度高于非糖尿病组(<0.05)。糖尿病组腔隙性脑梗死和多发性脑梗死发生率明显高于非糖尿病组(<0.01)。糖尿病组颈动脉粥样硬化斑块发生率明显高于非糖尿病组(<0.05)，且最大斑块的平均面积显著大于非糖尿病组(<0.01)。结论：与非糖尿病脑梗死患者相比，糖尿病脑梗死患者存在明显血脂异常，以血清TG、ApoB、TCHOL浓度增高为特点。糖尿病患者的血脂异常与其颈动脉粥样硬化斑块的形成以及动脉硬化性脑梗死病灶的发生可能有关。
目的：對2型糖尿病急性腦梗死患者的血脂及相關臨床特點進行分析。方法：迴顧性收集急性腦梗死患者116例，根據是否伴2型糖尿病分為糖尿病組70例和非糖尿病組46例。採集血清總膽固醇(TCHOL)、甘油三酯(TG)、空腹血糖(GLU)、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)、載脂蛋白A(ApoA)、載脂蛋白B(ApoB)及頭部MRI、頸動脈超聲檢查結果，進行統計學分析。結果：糖尿病組空腹GLU、TG、ApoB、TCHOL血清濃度高于非糖尿病組(<0.05)。糖尿病組腔隙性腦梗死和多髮性腦梗死髮生率明顯高于非糖尿病組(<0.01)。糖尿病組頸動脈粥樣硬化斑塊髮生率明顯高于非糖尿病組(<0.05)，且最大斑塊的平均麵積顯著大于非糖尿病組(<0.01)。結論：與非糖尿病腦梗死患者相比，糖尿病腦梗死患者存在明顯血脂異常，以血清TG、ApoB、TCHOL濃度增高為特點。糖尿病患者的血脂異常與其頸動脈粥樣硬化斑塊的形成以及動脈硬化性腦梗死病竈的髮生可能有關。
목적：대2형당뇨병급성뇌경사환자적혈지급상관림상특점진행분석。방법：회고성수집급성뇌경사환자116례，근거시부반2형당뇨병분위당뇨병조70례화비당뇨병조46례。채집혈청총담고순(TCHOL)、감유삼지(TG)、공복혈당(GLU)、저밀도지단백담고순(LDL-C)、고밀도지단백담고순(HDL-C)、재지단백A(ApoA)、재지단백B(ApoB)급두부MRI、경동맥초성검사결과，진행통계학분석。결과：당뇨병조공복GLU、TG、ApoB、TCHOL혈청농도고우비당뇨병조(<0.05)。당뇨병조강극성뇌경사화다발성뇌경사발생솔명현고우비당뇨병조(<0.01)。당뇨병조경동맥죽양경화반괴발생솔명현고우비당뇨병조(<0.05)，차최대반괴적평균면적현저대우비당뇨병조(<0.01)。결론：여비당뇨병뇌경사환자상비，당뇨병뇌경사환자존재명현혈지이상，이혈청TG、ApoB、TCHOL농도증고위특점。당뇨병환자적혈지이상여기경동맥죽양경화반괴적형성이급동맥경화성뇌경사병조적발생가능유관。
Objective:To explore the features of blood lipids, brain MRI and atherosclerosis of type 2 dia-betic patients with acute cerebral infarction. Methods:One hundred and sixteen cases with acute cerebral infarction were enrolled. Patients with diabetes were assigned into the diabetes group (n=70) and patients without diabetes the control group (n=46). Data of serum concentration of total cholesterol (TCHOL), triglyceride (TG), fasting glucose (GLU), low density lipoprotein cholesterol (LDL), high density lipopro-tein cholesterol (HDL), apolipoprotein A ( ApoA) and apolipoprotein B (ApoB) were collected and com-pared between the two groups. Data of brain MRI and carotid ultrasound detection were also collected and compared between the two groups. Results:The serum concentrations of GLU, TG, ApoB and TCHOL were significantly higher in the diabetes group than those in the control group ( <0.05). The incidence of multiple infarction and lacunar infarction were significantly higher in the diabetes group than those in the control group ( <0.01). The incidence of carotid artery plaques in the diabetes group was higher than that in the control group ( <0.05), and the plaques area was significantly bigger than that in the control group ( <0.01). Conclusion:Compared with patients without diabetes, type2 diabetic patients with acute cere-bral infarction have dyslipidemia characterized by elevated blood concentration of TG, ApoB and TCHOL. Dyslipidemia in patients with type2 diabetes mellitus probably plays an important role in the for-mation of carotid artery atherosclerotic plaques and cerebral infarction lesions.
