CAJ | 학술논문

　　目的：研究左乙拉西坦(LEV)对海人酸大鼠点燃癫痫模型的作用。方法：Wistar大鼠30只，随机分为假手术组、模型组及LEV组，各10只。模型组大鼠侧脑室注射制作海人酸点燃模型；LEV组大鼠于制作模型前3天每天予LEV灌胃(40 mg/kg)；假手术组侧脑室给予等量生理盐水。观察各组大鼠癫痫发作及神经元损伤情况。结果：LEV组大鼠癫痫模型点燃成功率、大鼠发作严重程度及海马CA3区神经元损伤程度均低于模型组。LEV组大鼠无死亡，模型组有大鼠发作致死。结论：LEV对海人酸诱导的大鼠癫痫模型有保护作用。
　　목적：연구좌을랍서탄(LEV)대해인산대서점연전간모형적작용。방법：Wistar대서30지，수궤분위가수술조、모형조급LEV조，각10지。모형조대서측뇌실주사제작해인산점연모형；LEV조대서우제작모형전3천매천여LEV관위(40 mg/kg)；가수술조측뇌실급여등량생리염수。관찰각조대서전간발작급신경원손상정황。결과：LEV조대서전간모형점연성공솔、대서발작엄중정도급해마CA3구신경원손상정도균저우모형조。LEV조대서무사망，모형조유대서발작치사。결론：LEV대해인산유도적대서전간모형유보호작용。
Objective:To investigate the effects of levetiracetam (LEV) on kainic acid (KA)-induced kin-dling of rats. Methods:Thirty Wistar rats were randomly divided into sham, model and LEV groups (n=10 respectively). Kindling models were induced in rats by intracerebroventricularl injection of KA. Rats in the LEV group received consecutively LEV treatment 3 days before intracerebroventricularl injection of KA whereas those in sham group were given equal saline. The achievement of ka-induced kindling, sever-ity of seizures and neuronal damage in CA3 of hippocampus were compared among three groups. Results:The ratio of KA-induced kindling and neuronal death in CA3 of the hippocampus in the LEV group were significantly lower than those in the model group. There was no death due to seizures in the LEV group, but in the model group. Conclusion:LEV could provide protective effect in KA-induced kindling of rats.