CAJ | 학술논문

　　目的：探讨高胆红素血症新生儿血β2微球蛋白水平的变化及临床意义。方法：分别检测30例高胆红素血症新生儿及30例生理性黄疸新生儿血总胆红素、间接胆红素、β2微球蛋白、肌酐及尿素氮水平。结果：高胆红素血症组新生儿血总胆红素、间接胆红素、β2微球蛋白水平明显高于生理性黄疸组新生儿(P＜0.01)；两组患儿血肌酐和尿素氮水平均在正常范围，且两组比较差异无统计学意义(P＞0.05)。高胆红素血症新生儿的血β2微球蛋白水平与总胆红素及间接胆红素水平呈正相关(P＜0.01)。结论：高胆红素血症新生儿存在明显的肾功能损伤，与肌酐、尿素氮相比，血β2微球蛋白水平可以早期、敏感地反应新生儿肾功能的损害。
　　목적：탐토고담홍소혈증신생인혈β2미구단백수평적변화급림상의의。방법：분별검측30례고담홍소혈증신생인급30례생이성황달신생인혈총담홍소、간접담홍소、β2미구단백、기항급뇨소담수평。결과：고담홍소혈증조신생인혈총담홍소、간접담홍소、β2미구단백수평명현고우생이성황달조신생인(P＜0.01)；량조환인혈기항화뇨소담수평균재정상범위，차량조비교차이무통계학의의(P＞0.05)。고담홍소혈증신생인적혈β2미구단백수평여총담홍소급간접담홍소수평정정상관(P＜0.01)。결론：고담홍소혈증신생인존재명현적신공능손상，여기항、뇨소담상비，혈β2미구단백수평가이조기、민감지반응신생인신공능적손해。
Objective:To investigate the changes and clinical significance of bloodβ2-microglobulin level of hyperbilirubinemianeonates.Methods:Theleveloftotalbilirubin,indirectbilirubin,β2-microglobulin,creatinineandurea nitrogen in blood of 30 hyperbilirubinemia neonates and 30 physiologic jaundice neonates were respectively detected. Results:The level of total bilirubin, indirect bilirubin,β2-microglobulin in blood of hyperbilirubinemia neonates were all obviouslyhigherthanthatofphysiologicjaundiceneonates(P<0.01).Thelevelofcreatinineandureanitrogeninblood ofhyperbilirubinemianeonatesandphysiologicjaundiceneonateswereallinnormalrange,andhadnoobviousdifferences (P>0.05).Forhyperbilirubinemianeonates,thelevelofβ2-microglobulininbloodwaspositivelycorrelatedwithlevelof total bilirubin and indirect bilirubin (P<0.01). Conclusions:Hyperbilirubinemia neonates have obvious impairment of renalfunction.Comparedwithlevelofcreatinineandureanitrogeninblood,β2-microglobulinlevelinbloodcanreportrenal functiondamageearlyandsensitively.